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NCT03906253Recruiting

Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

Source: ClinicalTrials.gov · Last updated 17 Jul 2026

Brief summary (registry, in English)

This study is following up on previous studies that have demonstrated that geriatric subjects respond different to ultraviolet B (UVB) light than young subjects. The treatment of geriatric skin with dermal rejuvenation therapies (dermabrasion, fractionated laser resurfacing) restores the appropriate UVB response. Ongoing studies have tested the ability of fractionated laser resurfacing (FLR) to assess how long this wounding effect lasts-and have found that this appears to be a durable response which lasts for at least two years. The findings that FLR protects geriatric skin at two years is the impetus for this study. This study is an interventional study to assess if FLR treatment of one forearm of geriatric subjects with multiple actinic keratosis will result in the short-term removal of actinic keratosis, and the long-term decrease in levels of future actinic keratosis and other non-melanoma skin cancers in comparison to the untreated arm. Study length and visit: The first part of the study is completed in 1 day then there are follow up visits at 90 days and every 6 months for 5 years.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
72 (estimated)
First submitted
4 Apr 2019
Start date
10 Jan 2018
Primary completion date
Dec 2028
Lead sponsor
Wright State University
Diseases
Melanoma
NCT number
NCT03906253

What you commit to

  • Study type: Interventional
  • Planned participants: 72
  • From 10 Jan 2018 to the primary completion date, Dec 2028
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Use of topical or oral anti-inflammatory medication or steroids
  • Current use of photosensitizing medication

Other illness

  • Uncontrolled Diabetes Mellitus
  • History of abnormal healing or scarring (i.e., keloids)
  • Any disease that gets worse while in the sun
  • Allergy to lidocaine

Other

  • Not able to comprehend procedures or risks versus benefits
  • Pregnant or nursing
  • Large tattoos on forearms

Who the study is looking for

  • Diagnosed with Actinic Keratosis within the past 6 months
  • At least 60 years of age, or older
  • Ability to comprehend procedures and risks versus benefits
  • Able to provide Informed Consent
  • Fair Skin (Fitzpatrick Type I or II)
  • Possess both Right and Left Forearms

Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Dayton VA Medical Center
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DaytonUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.