NCT03907631Active, not recruiting
Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC)
Elevate ASUC - Evaluating Clinical and Endoscopic Variables in Assessment, Treatment and Outcome Endpoints in Acute Severe Ulcerative Colitis
Source: ClinicalTrials.gov · Last updated 17 Feb 2026
Brief summary (registry, in English)
Up to one third of patients with Ulcerative Colitis (UC) will require hospitalisation for severe disease (ASUC - Acute Severe Ulcerative Colitis), often within the first 12 months of diagnosis. 30-40% of people admitted to hospital with ASUC will require colectomy during the emergency admission. Investigators will develop a multi-centre prospective inception cohort of patients with ASUC with homogeneously collected detailed longitudinal clinical, endoscopic and laboratory data.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 189 (actual)
- First submitted
- 5 Apr 2019
- Start date
- 18 Oct 2019
- Primary completion date
- 31 Jan 2024
- Lead sponsor
- Hull University Teaching Hospitals NHS Trust
- Diseases
- Ulcerative colitis
- NCT number
- NCT03907631
What you commit to
- Study type: Observational
- Participants enrolled: 189
- From 18 Oct 2019 to the primary completion date, 31 Jan 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior colitis related surgery - pouch, stoma
Other illness
- Crohn's disease
Other
- Admission for elective colectomy
- Infective colitis confirmed on stool culture, assays for C. difficile or cytomegalovirus
- Pregnancy
- Inability to sign consent
Who the study is looking for
- age 18 - 80 years.
- Confirmed acute severe ulcerative colitis based on modified Truelove and Witts criteria requiring hospital admission.
- Need for at least 2 days of intravenous steroids
- Able to sign consent
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Gastroenterology, Hull Royal Infirmary, Hull University Teaaching Hospitals NHS Trust Coordinator of this site? Confirm its status | Hull | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.