NCT03911726Recruiting
Do Antipsychotic Agents Induce Supersensitivity in Humans: A Combined PET/MRI Study in Patients With Schizophrenia
Source: ClinicalTrials.gov · Last updated 8 Sept 2026
Brief summary (registry, in English)
The aim of the present study is to detect changes in the dopamine system in the brain of patients with schizophrenia, especially when pretreated with antipsychotic medication. Here, the investigators want to find out whether the treatment with these drugs can cause permanent changes in docking points (receptors) of dopamine in the brain. It will be examined whether number and response of dopamine receptors is altered, which are associated with the onset of psychotic symptoms. For this purpose, a single PET/MR measurement will be performed in all participants. In total 140 volunteers, consisting of 30 healthy volunteers, 20 first-episode, drug-naive patients with schizophrenia and 90 pretreated patients with schizophrenia will be included over a time period of three years. In addition, the influence of nicotine consumption on dopamine receptors will be invesitgated by comparing data from smoking and non-smoking patients. In clinical practice, an elevation of dopamine action caused by alterations in receptors in the brain is of most importance. This may be the reason why the treatment with antipsychotic agents does not work in some patients. In addition, a permanent elevation of dopamine action is associated with permanent brain alterations by these drugs. The result can contribute to work out valuable indications, whether it makes sense to continue a long term therapy with antipsychotic drugs in a patient. But also the in-depth understanding of the impact of nicotine on the course of therapy can help to open up possibilities for improved drug treatment.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 140 (estimated)
- First submitted
- 9 Apr 2019
- Start date
- 1 Aug 2020
- Primary completion date
- Jun 2028
- Lead sponsor
- Central Institute of Mental Health, Mannheim
- Diseases
- Schizophrenia
- NCT number
- NCT03911726
What you commit to
- Study type: Interventional
- Planned participants: 140
- From 1 Aug 2020 to the primary completion date, Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in other clinical trials during or within six months prior to this clinical study.
- Participation in a study using ionising Radiation within the last five years.
- Alcohol abuse, alcohol dependence or addiction disease / abuse of dependence-inducing substances (excluding nicotine) in the history, additional exclusion criterion for healthy subjects: regular medication intake; within the last two weeks before PET/MR-measurement no drugs at all must be taken.
- Additional exclusion criterion for patients: other than the approved axis I diagnosis according to DSM-5. An axis II diagnosis is not a criterion for exclusion
Other illness
- Hypersensitivity against apomorphine or a chemically similar substance or one of the components of the applied medication.
- Medical or psychological conditions which may endanger a proper performance of the clinical trial.
- Physical disorders which interfere according to type and severity with the planned examinations, which could influence the parameter to be investigated or could compromise the subject during the examination procedure.
- Poor general condition.
Other
- Inability to comply with the study protocol.
- Limited or completely repealed legal capacity.
- For female participants: positive pregnancy test on the day of the study inclusion or on the day of the PET/MR-measurement.
- Acute suicidality or endangerment
Who the study is looking for
- Age: 18-65
- The subject is capable to understand scope and individual consequences of the clinical study.
- An informed consent is signed and personally dated by the subject. • No psychiatric disorder (DSM-5) currently, or in the medical history (ensured by a standardized psychiatric interview Mini International Neuropsychiatric Interview (M.I.N.I.)).
- Age: 18-65
- The criteria for schizophrenia after DSM-5 are met.
- The subject is capable to understand scope and individual consequences of the clinical study.
- For first-episode patients, no application of antipsychotic drugs in history. Other psychoactive substances (in particular antidepressants) are allowed if last application is at least three months ago and total Duration did not exceed three months. Benzodiazepines are allowed.
- For medically pretreated patients: at least one year pharmacotherapy with one of the following three substances: aripiprazole or quetiapine or risperidone. A medication break of - depending on the plasma level - two days (quetiapine) up to two weeks (aripiprazole) should be clinically defensible.
- An informed consent is signed and personally dated by the patient. For patients with legal support in addition: signature of the legal supervisor.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Central Institute of Mental Health Coordinator of this site? Confirm its status | Mannheim | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.