NCT03921827Completed
External Counterpulsation Therapy for Severe Steno-occlusive Intracranial Stenosis
External Counterpulsation Therapy for Symptomatic and Severe Steno-occlusive Disease of Intracranial Internal Carotid or Middle Cerebral Artery and Impaired Cerebral Vasodilatory Reserve
Source: ClinicalTrials.gov · Last updated 5 Dec 2025
Brief summary (registry, in English)
Intracranial stenosis is prevalent among Asians and constitute a common cause of cerebral ischemia. While the best medical therapy carries stroke recurrence rates in access of 10% per year, intracranial stenting was associated with unacceptable peri-procedural ischemic events. Cerebral ischemic events are strongly related to the severity of intracranial stenosis, being high in patients with severe intracranial stenosis with poor vasodilatory reserve. Enhanced External Counter-Pulsation (EECP) therapy is known to improve myocardial perfusion by facilitating the development of collateral blood vessels in the heart. The investigators hypothesize that EECP therapy may be useful in patients with severe stenosis of intracranial internal carotid (ICA) or middle cerebral artery (MCA).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 130 (actual)
- First submitted
- 14 Apr 2019
- Start date
- 8 Jan 2019
- Primary completion date
- 30 Mar 2024
- Lead sponsor
- National University of Singapore
- Diseases
- Stroke
- NCT number
- NCT03921827
What you commit to
- Study type: Interventional
- Participants enrolled: 130
- From 8 Jan 2019 to the primary completion date, 30 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of a documented aortic aneurysm/ dissection requiring surgical repair
Other illness
- Patients with atrial fibrillation/ arrhythmias.
- Within 2 weeks of cardiac catheterization or arterial puncture at femoral puncture site.
- Decompensated heart failure , usually class 3 or 4
- Persistent and uncontrolled hypertension (BP persistently \>160/100 mmHg)
- Bleeding diathesis
- Active thrombophlebitis/ venous disease of lower limbs
- Severe lower extremity vaso-occlusive disease
Other
- LV EF \<30%
- Moderate or severe AR
- Pregnancy
Who the study is looking for
- Patients with recent stroke/TIA and severe stenosis of intracranial ICA or MCA and impaired CVR within previous three months but not before 3 weeks after acute stroke. This is to differentiate between patients with a long-standing fixed-stenosis from patients with partially recanalized intracranial artery (masquerading as severe stenosis).
- Age \>21 years
Age in the registry: 21 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National University Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.