NCT03943641Completed
Dementia Risk Prediction Model: Development and Validation
Development and Validation of a Multivariable Dementia Risk Prediction Model in UK Adults Using Routinely Available Predictors
Source: ClinicalTrials.gov · Last updated 10 Dec 2024
Brief summary (registry, in English)
At present, there is no treatment for dementia that changes the course of the disease. However, it is now understood that the proteins in dementias such as Alzheimer's disease are present years before someone develops symptoms of dementia. Studies may therefore need to give potential treatments to patients before they develop symptoms of dementia. To do this, researchers need a way of predicting who will go on to develop dementia in the future. There are several ways of doing this, however, many of these methods are costly and difficult to implement at a population level - such as brain imaging, lumbar punctures or psychological tests. In this study, the investigators aim to develop a method of predicting who will go on to develop dementia (and dementia due to Alzheimer's disease) using only the sort of information that a general practitioner would have available to them. To do this, the investigators will develop a dementia prediction model using data from the Secure Anonymised Information Linkage (SAIL) Databank, which contains anonymised primary care, hospital admissions and mortality data for the population of Wales, United Kingdom (UK). They will then go on to test how well it performs in an external dataset, such as the UK's Clinical Practice Research Datalink (CPRD).
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 400000 (actual)
- First submitted
- 7 May 2019
- Start date
- 8 May 2019
- Primary completion date
- 5 Dec 2024
- Lead sponsor
- University of Edinburgh
- Diseases
- Alzheimer disease
- NCT number
- NCT03943641
What you commit to
- Study type: Observational
- Participants enrolled: 400000
- From 8 May 2019 to the primary completion date, 5 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- All-cause dementia code in any dataset prior to 1st January 2008 (i.e. dementia diagnosis at baseline)
Other
- Deprivation quintile missing for the start of follow-up (deprivation scores will probably not be missing at random)
Who the study is looking for
- Registered with a SAIL practice before 2008
- Aged between 60-79 during the study window (1st January 2008 to 31st December 2017)
- Aged 60-79 years by January 2008
Age in the registry: 60 years to 79 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Usher Institute, University of Edinburgh Coordinator of this site? Confirm its status | Edinburgh | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.