NCT03952351Active, not recruiting
Troponin in Acute Chest Pain to Risk Stratify and Guide EffecTive Use of Computed Tomography Coronary Angiography
Source: ClinicalTrials.gov · Last updated 26 Oct 2026
Brief summary (registry, in English)
Most patients presenting to hospital with symptoms of a heart attack are sent home without further tests once a heart attack has been ruled out. Current strategies to assess patients with a suspected heart attack involve blood tests to measure troponin, a protein released into the bloodstream when the heart muscle is damaged. Despite having had a heart attack ruled-out, some patients have unrecognised heart disease and are at risk of having a heart attack in the future. However, clinicians do not know what is the best approach to identify and treat these patients. This study will use a heart scan known as computed tomography coronary angiogram (CTCA) to look for unrecognised heart disease in patients who have had a heart attack ruled out. In an earlier study, the Investigators performed this scan in patients referred to the outpatient cardiology clinic with stable chest pain and found that this improved the diagnosis of heart disease, leading to improvement in patient care that prevented future heart attacks. Previous research from the Investigators has also found that troponin levels below those used to diagnose a heart attack may help to identify those who are at greater risk of having a heart attack in the future. The aim of this study is to find out if patients with these low levels of troponin, where a heart attack has been ruled out, will benefit from CTCA to look for unrecognised coronary heart disease.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 3170 (actual)
- First submitted
- 14 May 2019
- Start date
- 31 Jan 2026
- Primary completion date
- 31 Mar 2026
- Lead sponsor
- University of Edinburgh
- Diseases
- Coronary artery disease
- NCT number
- NCT03952351
What you commit to
- Study type: Interventional
- Participants enrolled: 3170
- From 31 Jan 2026 to the primary completion date, 31 Mar 2026
- 9 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous randomisation into the trial
Other illness
- Diagnosis of myocardial infarction during index presentation
- Patient inability to undergo CT scanning, e.g. due to severe renal failure (estimated glomerular filtration rate <30 mL/min) or major allergy to iodinated contrast media
- Further investigation for coronary artery disease would not be in the patient's interest, e.g. due to limited life expectancy, quality of life or functional status
Other
- Clear alternative diagnosis or participant requires further inpatient clinical assessment
- Recent CTCA or invasive coronary angiogram (within 1 year)
- Current pregnancy or breast feeding
- Inability to give informed consent
Who the study is looking for
- Presenting to hospital with symptoms of suspected acute coronary syndrome
- Age 18 years and over
- Maximum high-sensitivity cardiac troponin concentration between 5ng/L and the 99th percentile
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (9)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NHS Lothian Coordinator of this site? Confirm its status | Edinburgh | United Kingdom | Unknown status |
| NHS Greater Glasgow and Clyde Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Unknown status |
| Lewisham & Greenwich NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Milton Keynes University NHS Hospital Coordinator of this site? Confirm its status | Milton Keynes | United Kingdom | Unknown status |
| University Hospitals Plymouth NHS Trust Coordinator of this site? Confirm its status | Plymouth | United Kingdom | Unknown status |
| Royal Berkshire NHS Foundation Trust Coordinator of this site? Confirm its status | Reading | United Kingdom | Unknown status |
| University Hospital Southampton NHS Trust Coordinator of this site? Confirm its status | Southampton | United Kingdom | Unknown status |
| North Tees NHS Hospital Foundation Coordinator of this site? Confirm its status | Stockton | United Kingdom | Unknown status |
| Torbay & South Devon NHS Foundation Trust Coordinator of this site? Confirm its status | Torquay | United Kingdom | Unknown status |
Related publications
- Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain.N Engl J Med · 2026 · PMID 42670980
This page is information, not medical advice. Discuss any trial with your doctor.