NCT03968445CompletedPhase 1
Neuroinflammation After Myocardial Infarction - Imaging Substudy
Source: ClinicalTrials.gov · Last updated 26 Aug 2026
Brief summary (registry, in English)
The purpose of the study is to see if positron emission tomography and magnetic resonance imaging (PET/MRI) with an investigational drug called \[18F\]DPA-714 will show inflammation in the brain after a heart attack. This study may help physicians and researchers better understand the role of brain inflammation in heart disease and develop new treatments to protect the brain.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 6 (actual)
- First submitted
- 16 May 2019
- Start date
- 17 Oct 2019
- Primary completion date
- 17 Aug 2026
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Coronary artery disease
- NCT number
- NCT03968445
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 6
- From 17 Oct 2019 to the primary completion date, 17 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior myocardial infarction
- Prior coronary artery bypass grafting
- Prior angioplasty and/or coronary artery stent placement (PCI group only)
Other illness
- History of traumatic head injury defined by a loss of consciousness ≥30 minutes or seizure at the time of injury
- Diagnosis of dementia
Other
- Contraindication to MRI
- Pregnancy
- Lactation
- Serious medical co-morbidity that may interfere with participation
- Severe anemia
- Diagnosis of major depression
- Low affinity binder for TSPO ligands based on genotyping for SNP rs6971.
Who the study is looking for
- Participation in UAB IRB protocol "Neuroinflammation After Acute Myocardial Infarction" (IRB-300002751, PI Lazar).
- 21 years of age or older
- . English speaking with at least 8th grade education
- High or mixed affinity binder for TSPO ligands based on genotyping for single nucleotide polymorphism (SNP) rs6971.
- Admission to UAB Hospital for ST-elevation acute myocardial infarction (AMI) and treatment with percutaneous coronary intervention (PCI) OR Undergoing elective percutaneous coronary intervention (PCI)
Age in the registry: 21 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham Medical Center Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.