NCT03971500Active, not recruiting
1-month vs 12-month DAPT for ACS Patients Who Underwent PCI Stratified by IVUS: IVUS-ACS and ULTIMATE-DAPT Trials
Comparison of 1-month Versus 12-month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents Guided by Either Intravascular Ultrasound or Angiography in Patients With Acute Coronary Syndrome: The Prospective, Multicenter, Randomized, Placebo-controlled IVUS-ACS and ULTIMATE-DAPT Trials
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
Prospective, multicenter, randomized, double-blind, placebo-controlled trials.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 3710 (actual)
- First submitted
- 30 May 2019
- Start date
- 20 Aug 2019
- Primary completion date
- 27 Oct 2023
- Lead sponsor
- Nanjing First Hospital, Nanjing Medical University
- Diseases
- Coronary artery disease
- NCT number
- NCT03971500
What you commit to
- Study type: Interventional
- Participants enrolled: 3710
- From 20 Aug 2019 to the primary completion date, 27 Oct 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Stroke within 3 months or any permanent neurologic deficit, and prior intracranial bleed, or any intracranial disease such as aneurysm or fistula
- Previous coronary artery bypass graft (CABG)
- Any planned surgery within 90 days
- Any reason why any antiplatelet therapy might need to be discontinued within 12 months
Other illness
- Any condition likely to interfere with study processes including medication compliance or follow-up visits (e.g. dementia, alcohol abuse, severe frailty, long distance to travel for follow-up visits, etc.)
Lab values
- Severe chronic kidney disease defined as an estimated glomerular filtration rate (eGFR) \< 20 ml/min/1.73m\^2
- Platelet count \< 100,000 mm\^3
Other
- Unable or unwilling to provide informed consent
- Need for chronic oral anticoagulation (warfarin/coumadin or direct oral anticoagulants)
- Contraindication to aspirin
- Contraindication to ticagrelor
- Liver cirrhosis
- Women of child-bearing potential
- Life expectancy \< 1 year
Who the study is looking for
- Enrollment into the study will require meeting at least one of these clinical syndromes within 1 month.
- Unstable angina, defined as rest pain for 5-30 minutes or deteriorative exertional angina with either a) transient ST segment depression or elevation, or b) angiography showing a visually estimated diameter stenosis ≥90% or a ruptured plaque or thrombotic lesion
- Non-ST elevation myocardial infarction (NSTEMI), defined as positive troponin consistent with clinical syndrome.
- ST elevation MI (STEMI)
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nanjing First Hospital Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.