NCT03972514Active, not recruiting
Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.
Prospective Observational Trial of the Impact of Radiation Dose on Brain Morphology, Volumetric Changes, Endocrine Function, and Neurocognitive Function Following Cranial Radiation Therapy in Children With Brain and Skull Base Tumors.
Source: ClinicalTrials.gov · Last updated 14 Jul 2026
Brief summary (registry, in English)
This is a prospective, observational clinical trial investigating the morphological and volumetric changes in the brain following cranial Radiation Therapy in pediatric patients with brain or skull base tumors.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 60 (actual)
- First submitted
- 25 Apr 2019
- Start date
- 8 Mar 2019
- Primary completion date
- Mar 2030
- Lead sponsor
- Baptist Health South Florida
- Diseases
- Childhood cancers
- NCT number
- NCT03972514
What you commit to
- Study type: Observational
- Participants enrolled: 60
- From 8 Mar 2019 to the primary completion date, Mar 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient receiving treatment with non-curative intent
Other
- Patient cannot undergo MRI without contrast as per standard of care
- Patient and family do not speak English or Spanish
- Patients with an expected 3-year overall survival less than 50%
Who the study is looking for
- Patient (parent) must give study-specific informed consent on an IRB-approved consent prior to any research related procedures or study treatment. Written assent will be obtained as per Institutional guidelines.
- Patients (Age equal to or less than 35 years old) that are planned to receive photon or proton RT to the brain according to standard of care are eligible to participate.
- Patients that are planned to receive fractionated RT at 1.2-2.0 Gy RBE dose per fraction per standard of care are eligible to participate. If patients are planned to receive an alternative dose/fractionation regimen, then they should be treated according to standard of care and should not be enrolled.
- Zubrod/Eastern Cooperative Oncology Group (ECOG) Performance Status ≤1
Age in the registry: 1 year to 35 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Miami Cancer Institute at Baptist Health South Florida Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.