Integrated HIV Prevention and HCV Care for PWID

Prior treatment

• have prior HCV treatment failure with direct-acting antiviral (DAA) regimens (Except those who were treated, cured the virus, but were re-infected with a new virus)
• are currently on PrEP and/or HCV treatment.

Other illness

• have any disabling mental conditions as assessed by medical history and clinical assessment that in the opinion of the study physician precludes safe participation in the study or ability to provide fully informed consent.
• have chronic renal failure
• have or have history of decompensated cirrhosis
• are HIV-positive or have symptoms of an acute HIV infection
• have an allergy or contraindication to one of the study medications

Lab values

• have any disabling medical conditions as assessed by medical history, physical exam, vital signs, and/or laboratory assessments that in the opinion of the study physician preclude safe participation in the study or ability to provide fully informed consent.

Other

• Individuals will be excluded from the RCT if they:
• are pregnant (verified via pregnancy test), are planning to be pregnant during the course of the study, or breastfeeding
• are currently in prison, in any inpatient overnight facility as required by court of law or have a pending legal action, which may prevent an individual from completing the study.

• Individuals must meet the following criteria to be eligible to participate in the RCT:
• Be 18-64 years of age
• report injection drug use in the past 6-months
• be HIV negative
• provide informed consent
• complete a medical release form
• report living in the vicinity and being able to return for follow-up over 18-months
• be willing to use a medically acceptable form of contraception throughout the study duration (for women of childbearing potential)
• be able to communicate in English or French (site dependent)
• be receiving services at an opioid agonist therapy clinic or a syringe access program
  • Individuals must meet the following criteria to be eligible to participate in the qualitative interview:
• have completed the first 6 months of RCT follow up (RCT participant interviews);
• provide informed consent;
• have contributed to assessments/interviews, intervention and/or treatment follow-ups (staff interviews).