NCT03984396Completed
Optimal Medication Management in Alzheimer's Disease and Dementia
Source: ClinicalTrials.gov · Last updated 1 Feb 2024
Brief summary (registry, in English)
The study objective is to conduct a pragmatic deprescribing intervention for people with Alzheimer's Disease or Related Dementia with Multiple Chronic Conditions (ADRD-MCC) so that these patients are on 'just right' medication regimens. The intervention will be a pragmatic, cluster randomized trial of medication optimization through increased awareness of deprescribing for the ADRD-MCC population. It will be delivered in primary care at the clinic level with a wait-list control design. As a pragmatic intervention it is designed to be relatively simple, have broad inclusion/exclusion criteria, and be implemented across the Kaiser Permanente Colorado (KPCO) system. The intervention will have two components: a patient/care partner component focused on education and activation about potential deprescribing including sending out a brochure, and a clinician component focused on increasing clinician awareness through monthly Tip Sheets about options and processes for deprescribing in the ADRD-MCC population linked to upcoming visits. The intervention will take place at 18 primary care offices in the Denver-Boulder service delivery area with 9 as initial intervention sites and 9 as delayed intervention sites.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 7398 (actual)
- First submitted
- 24 May 2019
- Start date
- 6 Mar 2019
- Primary completion date
- 1 Apr 2021
- Lead sponsor
- Kaiser Permanente
- Diseases
- Alzheimer disease
- NCT number
- NCT03984396
What you commit to
- Study type: Interventional
- Participants enrolled: 7398
- From 6 Mar 2019 to the primary completion date, 1 Apr 2021
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Patient Inclusion Criteria:
- Age\>=65
- Bonded to a primary care physician (PCP) in the Kaiser Permanente Colorado (KPCO) - Denver-Boulder service area
- Diagnosis of Alzheimer's Dementia or Related Dementia or Mild Cognitive Impairment (MCI) from ICD-9 or ICD-10 visit codes or from the problem list in the Electronic Health Record (EHR)
- One or more additional chronic conditions from a list of 86 chronic medical conditions
- Be taking 5 or more chronic medications (defined as a 28+ days' supply of medication on the eligibility date; excluding non-indicated medications such as vaccines and anesthetics based on 2-digit GPI codes
- Of this eligible population, those who have at least one visit with a PCP during the intervention period will receive the patient portion of the intervention.
- Patient Exclusion Criteria:
- Individuals residing in long term care facilities or enrolled in hospice care at baseline
- Individuals residing at home but receiving all their primary care through the KPCO Complex Care Home Rounding service which replaces primary care delivery
- Clinician Inclusion Criteria:
- \* PCP for adult patients in the KPCO Denver-Boulder service area.
- Clinician Exclusion Criterion:
- \* PCP for adult patients at the Longmont Medical Office since Longmont was the pilot study site.
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kaiser Permanente Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.