NCT03988595Active, not recruitingPhase 1
Exercise Treatment With Standard Therapy for Metastatic Breast Cancer
Phase 1 Trial of Exercise Treatment With Concurrent First-Line Therapy for Hormone Receptor Positive Metastatic Breast Cancer
Source: ClinicalTrials.gov · Last updated 31 Aug 2026
Brief summary (registry, in English)
This study will test any good and bad effects of aerobic exercise performed while you are receiving the usual first-line treatment for metastatic breast cancer. The researchers think that exercise helps delay the development of resistance to hormone therapy while slowing the growth of tumors.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 54 (actual)
- First submitted
- 13 Jun 2019
- Start date
- 12 Jun 2019
- Primary completion date
- 1 Aug 2027
- Lead sponsor
- Memorial Sloan Kettering Cancer Center
- Diseases
- Metastatic breast cancer
- NCT number
- NCT03988595
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 54
- From 12 Jun 2019 to the primary completion date, 1 Aug 2027
- 10 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent participation in weight loss or other exercise programs
Other illness
- Mental impairment leading to inability to cooperate
Other
- Life expectancy \<6 months
- Enrollment onto any other therapeutic investigational study
Who the study is looking for
- Patients with histologically-confirmed, HR-positive (ER and/or PR), HER2-negative metastatic breast cancer (MBC)
- Postmenopausal status defined by lack of menses for 2 years, oophorectomy, or medical ovarian suppression
- Receiving first line endocrine-based therapy (tamoxifen, aromatase inhibitor, or fulvestrant; concurrent molecular therapy also allowed)
- Sedentary (i.e., \<60 minutes / week of exercise)
- Age \>18 years
- BMI ≥ 18.5
- Cleared for exercise participation as per screening clearance via PAR-Q+
- Cleared for study participation as per screening consultation with an MSK Exercise Physiologist
- Willingness to comply with all study-related procedures
- Patients with "treated and stable" brain lesions of a duration of ≥ 2 months may be enrolled
Age in the registry: 19 years to - · Sex: Female · Does not accept healthy volunteers
Sites (10)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins Hospital (Data Collection Only) Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) Coordinator of this site? Confirm its status | Basking Ridge | United States | Unknown status |
| Memorial Sloan Kettering Cancer Center @ Suffolk (Limited protocol activity) Coordinator of this site? Confirm its status | Commack | United States | Unknown status |
| Memorial Sloan Kettering Westchester (Limited Protocol Activities) Coordinator of this site? Confirm its status | Harrison | United States | Unknown status |
| Indiana University (Data Collection Only) Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Memorial Sloan Kettering Monmouth (Limited Protocol Activities) Coordinator of this site? Confirm its status | Middletown | United States | Unknown status |
| Memorial Sloan Kettering Bergen (Limited Protocol Activities) Coordinator of this site? Confirm its status | Montvale | United States | Unknown status |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Montefiore Health Systems (Montefiore Medical Center) (Data Collection Only) Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| Memorial Sloan Kettering Nassau (Limited Protocol Activities) Coordinator of this site? Confirm its status | Uniondale | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.