NCT03996590Active, not recruiting
Wessex Asthma Cohort of Difficult Asthma
WATCH (Wessex AsThma CoHort of Difficult Asthma): A Longitudinal Cohort Study to Facilitate Better Understanding and Management of Difficult Asthma Encountered in Clinical Practice
Source: ClinicalTrials.gov · Last updated 19 Jan 2024
Brief summary (registry, in English)
Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asthma still represents a significant health and economic burden worldwide. Why some individuals should continue to suffer remains unclear. The Wessex Asthma Cohort of Difficult Asthma (WATCH) is an ongoing 'real-life', prospective study of patients in the University Hospital Southampton Foundation Trust (UHSFT) Difficult Asthma service. Research data capture is aligned with the extensive clinical characterisation required of a commissioned National Health Service (NHS) Specialist Centre for Severe Asthma. Data acquisition includes detailed clinical, health and disease-related questionnaires, anthropometry, allergy and lung function testing, radiological imaging (in a small subset) and collection of biological samples (blood, urine and sputum). Prospective data are captured in parallel to clinical follow up appointments, with data entered into a bespoke database. The pragmatic ongoing nature of the WATCH study allows comprehensive assessment of the real world clinical spectrum seen in a Specialist Asthma Centre and allows a longitudinal perspective of deeply phenotyped patients. It is anticipated that the WATCH cohort would act as a vehicle for potential collaborative asthma studies and will build upon our understanding of mechanisms underlying difficult asthma.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 566 (actual)
- First submitted
- 20 Jun 2019
- Start date
- 22 Apr 2015
- Primary completion date
- 31 Dec 2050
- Lead sponsor
- University Hospital Southampton NHS Foundation Trust
- Diseases
- Asthma
- NCT number
- NCT03996590
What you commit to
- Study type: Observational
- Participants enrolled: 566
- From 22 Apr 2015 to the primary completion date, 31 Dec 2050
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any patients who are not on high-dose therapies, with or without the addition of continuous or frequent use of oral steroids (or steroid sparing therapies), as per the BTS (British Thoracic Society) Adult Asthma Management Guidelines (2016).
Other
- Asthma patients who are not referred to the Adult or Transitional Regional Asthma Clinics at participating hospitals.
Who the study is looking for
- All patients referred to the Adult or Transitional Regional Asthma Clinics at participating hospitals.
- On high-dose therapies, with or without the addition of continuous or frequent use of oral steroids (or steroid sparing therapies), as defined by the BTS (British Thoracic Society) Adult Asthma Management Guidelines (2016).
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Isle of Wight NHS Trust Coordinator of this site? Confirm its status | Newport | United Kingdom | Unknown status |
| Portsmouth Hospitals NHS Trust Coordinator of this site? Confirm its status | Portsmouth | United Kingdom | Unknown status |
| University Hospital Southampton NHS Foundation Trust Coordinator of this site? Confirm its status | Southampton | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.