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NCT04000971Completed

Coordinated, Collaborative, Comprehensive, Family-based, Integrated, Technology-enabled Stroke Care

C3FIT (Coordinated, Collaborative, Comprehensive, Family-based, Integrated, Technology-enabled Care): A Randomized Trial for Stroke

Source: ClinicalTrials.gov · Last updated 15 May 2026

Brief summary (registry, in English)

Stroke is the 5th leading cause of death and the leading cause of adult disability in the United States (US). Stroke is a complex disease with multiple interacting risk factors (including genetic, high blood pressure and cholesterol, and lifestyle factors like smoking, diet, and exercise) that lead to initial and recurrent stroke. Up to 90% of stroke survivors have some functional deficit that impacts both physical and mental health.

Status (registry)
Completed
Study type
Interventional
Enrollment
1196 (actual)
First submitted
25 Jun 2019
Start date
25 Feb 2020
Primary completion date
30 Sept 2024
Lead sponsor
Vanderbilt University Medical Center
Diseases
Stroke
NCT number
NCT04000971

What you commit to

  • Study type: Interventional
  • Participants enrolled: 1196
  • From 25 Feb 2020 to the primary completion date, 30 Sept 2024
  • 21 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Patients with a planned admission to hospice care prior to consent.

Other illness

  • Clinical transient ischemic attack (TIA)38-41 is excluded even if there is a computerized tomography (CT) or magnetic resonance imaging (MRI) lesion corresponding to the clinical syndrome at presentation.
  • Patients not anticipated to survive for 1-year due to neurological or other medical status (i.e., advanced cancer, hospice care, heart disease, etc.).

Other

  • Already enrolled or planned enrollment in another clinical trial for which participation in C3FIT would be compromised with regard to follow-up assessment of outcomes or continuation in C3FIT.
  • Patients who in the opinion of the site investigator cannot be involved in follow up care.
  • Inability or unwillingness of subject or legal guardian/representative to understand and cooperate with study procedures or provide informed consent.

Who the study is looking for

  • Age 18+.
  • Clinical diagnosis of acute stroke with brain imaging compatible with intracerebral hemorrhage or ischemic stroke (including normal brain scan); see International Classification of Disease 10 (ICD 10) codes.
  • English or Spanish speaking subjects.
  • Patient admitted within 7 days of their index stroke event.
  • Patient is discharged alive and not to hospice care.
  • Patient living at discharge within the geography of recruitment for that C3FIT site.
  • Pre-morbid Modified Rankin Score (mRS) score of 0-1.
  • Patient and/or surrogate give consent to participate after an informed consent process.
  • Patients who go to rehabilitation inpatient therapy or other care facilities are eligible, as long as they reside in the geographic are of recruitment and do not go to hospice care.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (21)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University of New Mexico Health Sciences Center
Coordinator of this site? Confirm its status
AlbuquerqueUnited StatesUnknown status
Emory University/Grady Health
Coordinator of this site? Confirm its status
AtlantaUnited StatesUnknown status
Augusta University Medical Center
Coordinator of this site? Confirm its status
AugustaUnited StatesUnknown status
University of Alabama at Birmingham
Coordinator of this site? Confirm its status
BirminghamUnited StatesUnknown status
Medical University of South Carolina
Coordinator of this site? Confirm its status
CharlestonUnited StatesUnknown status
Northwestern University
Coordinator of this site? Confirm its status
ChicagoUnited StatesUnknown status
Ohio Health Riverside Methodist Hospital
Coordinator of this site? Confirm its status
ColumbusUnited StatesUnknown status
Doctors Hospital Renaissance
Coordinator of this site? Confirm its status
EdinburgUnited StatesUnknown status
Hartford Hospital
Coordinator of this site? Confirm its status
HartfordUnited StatesUnknown status
Mayo Clinic
Coordinator of this site? Confirm its status
JacksonvilleUnited StatesUnknown status
Johnson City Medical Center at Ballad Health
Coordinator of this site? Confirm its status
Johnson CityUnited StatesUnknown status
University of Kansas Medical Center
Coordinator of this site? Confirm its status
Kansas CityUnited StatesUnknown status
Covenant Health Fort Sanders Regional Medical Center
Coordinator of this site? Confirm its status
KnoxvilleUnited StatesUnknown status
Intermountain
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Las VegasUnited StatesUnknown status
University of Louisville Hospital
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LouisvilleUnited StatesUnknown status
University of Wisconsin - Madison
Coordinator of this site? Confirm its status
MadisonUnited StatesUnknown status
Baptist Memorial Hospital
Coordinator of this site? Confirm its status
MemphisUnited StatesUnknown status
Vanderbilt University Medical Center
Coordinator of this site? Confirm its status
NashvilleUnited StatesUnknown status
Mayo Clinic Hospital
Coordinator of this site? Confirm its status
PhoenixUnited StatesUnknown status
University of Pittsburgh Medical Center
Coordinator of this site? Confirm its status
PittsburghUnited StatesUnknown status
Penn State
Coordinator of this site? Confirm its status
State CollegeUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.