Advanced GC Multi-omic Characterization in EU and CELAC Populations

Criteria the registry did not label

• Cases:
• Inclusion criteria:
  • Subjects ≥18 years old.
  • GC diagnosis stages III and IV (including gastroesophageal junction cancer) and/or a gastroscopy indication due to the high diagnostic suspicion of GC as part of the study of his disease.
  • Has given and signed the IC to participate in this study.
• Exclusion criteria:
  • Patients diagnosed with GC early disease (stage I and II) suitable for resectable strategy.
• Withdrawal criteria:
  • Patients initially recruited with high suspicion of GC diagnosis but not confirmed by the pathological report.
  • Controls:
• Inclusion criteria (only for microbiome analysis):
  • Subjects ≥18 years old.
  • Subjects to whom a gastroscopy is indicated within clinical care and is confirmed absent of GC in the same centres will be matched in age (+/- 10 years), gender and pertaining from the same region of the GC case.
  • Has given and signed the IC to participate in this study.
• Exclusion criteria:
  • Subjects from a different geographic area from the cases.
  • Patients with high suspicion of GC.
  • Patients with previous histopathologic diagnosis of peptic (gastric or duodenal) ulcer disease and/or atrophy or intestinal metaplasia.
  • Patients that have received antimicrobials during the 4 weeks period prior to the endoscopy.
  • Patients that have received proton pump inhibitors or H2-receptor antagonists, at least 2 weeks prior to the endoscopy