Fact CheckerSign in

NCT04018105Completed

Influence of Preprandial Metformin Administration on Carbohydrate Absorption

Influence of Preprandial Metformin Administration on Carbohydrate Absorption: Pilot Randomized Controlled Study

Source: ClinicalTrials.gov · Last updated 22 Apr 2026

Brief summary (registry, in English)

Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption. It is usually recommended to take metformin during the meal to decrease gastrointestinal side effects. However, if metformin decreases carbohydrate absorption, this might not be the most efficient intake. To study the influence of preprandial metformin administration on carbohydrate absorption, it will repeat 3 oral glucose tolerance test on obese dysglycemic patients, without metformin or with metformin administer 30 or 60 minutes before. We will also evaluate how it impacts gastrointestinal tolerance.

Status (registry)
Completed
Study type
Interventional
Enrollment
1 (actual)
First submitted
10 Jul 2019
Start date
28 Jul 2021
Primary completion date
4 Apr 2025
Lead sponsor
University Hospital, Lille
NCT number
NCT04018105
EudraCT number
2019-001175-36

What you commit to

  • Study type: Interventional
  • Participants enrolled: 1
  • From 28 Jul 2021 to the primary completion date, 4 Apr 2025
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Treatment that might interfere with carbohydrate absorption (anti diabetic medication, antibiotics, probiotics, steroids)

Other illness

  • Organ failure
  • Inflammatory Bowel Disease

Lab values

  • No dysglycemia (HbA1c \<6,0%)
  • Anemia (Hb \<12 g/dL)

Other

  • No obesity (BMI \< 30 kg/m2)

Who the study is looking for

  • Obesity (BMI ≥30 kg/m2)
  • Dysglycemia (HbA1c≥ 6,0 %)
  • No anti diabetic medication

Age in the registry: 18 years to 60 years · Sex: Female · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.