NCT04025840Active, not recruitingPhase 4
Perioperative Epidural Block and Dexamethasone in Pancreatic Cancer Surgery
Effect of Perioperative Epidural Block and Dexamethasone on Outcome of Patients Undergoing Pancreatic Cancer Surgery: a 2×2 Factorial Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 31 Jul 2025
Brief summary (registry, in English)
Pancreatic cancer remains a devastating disease with an average 5-year survival rate of about 3-5%. Previous retrospective studies showed that perioperative epidural block and/or dexamethasone are associated with improved outcome after cancer surgery. This randomized trial aims to investigate the effect of perioperative epidural block and/or dexamethasone on long-term survival in patients following pancreatic cancer surgery.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 260 (actual)
- First submitted
- 16 Jul 2019
- Start date
- 11 Sept 2019
- Primary completion date
- 22 Oct 2024
- Lead sponsor
- Peking University First Hospital
- Diseases
- Pancreatic cancer
- NCT number
- NCT04025840
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 260
- From 11 Sept 2019 to the primary completion date, 22 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous surgery for pancreatic cancer, scheduled to undergo resurgery for recurrence or metastasis;
- Complicated with primary malignant tumor in other organ(s), either previously or at present;
- Complicated with autoimmune diseases, receiving either glucocorticoids or other immunosuppressants before surgery;
Other illness
- Clinical evidence of unresectable pancreatic cancer or plan to undergo biopsy;
- Unable to complete preoperative evaluation due to severe dementia, language barrier, coma, or end-stage diseases;
- Contradictions to epidural anesthesia, including spinal malformation, history of spinal surgery, coagulation disorder, suspected infection at the site of puncture, or severe low back pain;
- Other conditions that are considered unsuitable for study participation;
Lab values
- Severe hepatic dysfunction (Child-Pugh C), severe renal insufficiency (serum creatinine \>442 µmol/L or requirement of renal replacement therapy), or American Society of Anesthesiologists classification ≥V；
Other
- Refused to participate in the study.
Who the study is looking for
- Age ≥45 and \<90 years;
- Clinically diagnosed as resectable or possibly resectable pancreatic cancer and scheduled to undergo radical surgery;
- Agreed to receive epidural block and postoperative patient-controlled analgesia;
- Agreed to participate in the study and provided written informed consent.
Age in the registry: 45 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Peking University First Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.