NCT04033510Completed
Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)
Source: ClinicalTrials.gov · Last updated 2 Nov 2026
Brief summary (registry, in English)
Objectives: * First, to determine if patients with a history of AF have acute measurable changes in cognitive functioning while in an episode of AF. * Second, to collect basic insight into what specific physiologic (blood pressure, pulse oximetry, heart rate, temperature) and pharmacologic (antiarrhythmic medications, rate control medications, anticoagulants, antiplatelet medications, etc.) factors minimize the neurological impact on patients while they are in AF. It is hypothesized that when using a tablet-based cognitive testing software - Cambridge Cognition (specifically to assess executive function, learning and working memory: Rapid Visual Information Processing test, Spatial Working Memory/Spatial Span Task tests, One touch Stockings of Cambridge test, Cambridge Gambling Task, Multitasking Test/Intra-Extra Dimensional Set shift tests) - a significant difference will be noted between how the patients perform while in atrial fibrillation compared to the patients' performance while in normal sinus rhythm.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 600 (actual)
- First submitted
- 24 Jul 2019
- Start date
- 14 Aug 2019
- Primary completion date
- 25 Nov 2024
- Lead sponsor
- David Brunk, PA-C, MMS
- Diseases
- Atrial fibrillation
- NCT number
- NCT04033510
What you commit to
- Study type: Observational
- Participants enrolled: 600
- From 14 Aug 2019 to the primary completion date, 25 Nov 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who had coronary bypass surgery during their life time.
- Patients with a previously documented history of post-pump syndrome during their life time.
Other illness
- Patients with presence of, or medical diagnosis of cognitive impairment (dementia, multiple sclerosis, traumatic brain injury, etc.).
Other
- Patients with presence of, or medical diagnosis of Transient Ischemic Attack (TIA) or Cerebral Vascular Accident (CVA).
- Female patients who are pregnant or post-partum.
- Individuals unwilling or unable to take an anticoagulant.
Who the study is looking for
- Subjects who are patients at CSC or Penrose-St. Francis Health Services.
- Subjects actively in an episode of paroxysmal, or persistent AF (who are expected to receive treatment and converted back to normal rhythm (through antiarrhythmic drug therapy, direct current cardioversion, ablation or Maze/Minimally invasive Maze procedure).
- Subjects with a history of AF who have had \>3 documented episodes of AF over the preceding 12 months and meet all other inclusion/exclusion criteria can pre-enroll. The cognition tests will be administered during the patient's next captured AF episode.
Age in the registry: 35 years to 80 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Penrose St. Francis Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.