NCT04038697Completed
Ischemic Conditioning Improves Walking Function Post Stroke
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
This innovative study will address scientific and clinical areas relatively unexplored in chronic stroke that could lead to greater recovery of walking. Ischemic Conditioning (IC) is a non-invasive, simple procedure that improves motor function, exercise performance and cardiovascular function in healthy controls, but it has never been applied to the stroke population. We postulate that IC enhances the recruitment of motoneurons and results in positive neural adaptations, improves vascular endothelial function and peripheral blood flow, and together these improvements result in an increased capacity to exercise and faster walking speed. Future studies will examine the effects of IC and traditional therapy at different time points of recovery post stroke, durability of IC, molecular mechanisms of neural and cardiovascular adaptation and the efficacy compared with other adjuncts.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 132 (actual)
- First submitted
- 25 Jul 2019
- Start date
- 20 Dec 2018
- Primary completion date
- 16 Dec 2025
- Lead sponsor
- Medical College of Wisconsin
- Diseases
- Stroke
- NCT number
- NCT04038697
What you commit to
- Study type: Interventional
- Participants enrolled: 132
- From 20 Dec 2018 to the primary completion date, 16 Dec 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- history of deep vein thrombosis or any condition in which transient ischemia to the lower extremity is contraindicated
- history of substance abuse
- history of head trauma
- comorbid neurological disorder
- any uncontrolled medical condition
- any condition where fatiguing contractions or resisted leg contractions are contraindicated
- Those listed above for stroke survivors
- History of Stroke
Other
- inability to follow 2 step commands
- chronic low back or hip pain
- pacemaker
- inability to walk for 5 minute bouts on a treadmill with a harness supporting up to 50% of the body weight at 80% of over-ground self-selected walking speed.
Who the study is looking for
- be ≥ 1 year post diagnosis of a unilateral, cortical stroke and have residual lower extremity paresis
- be between the ages of 18-85
- be able to give informed consent
- walk slower than normative values based on age and sex
- be between ages of 18-85
- be able to give informed consent
Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Marquette University Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.