NCT04056247Active, not recruiting
Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments
PROPHETIC - Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
The PROPHETIC study is a prospective, multi-center, international clinical study aimed at developing an algorithm to predict patient outcomes. The study involves analyzing the proteomic profiles of patients undergoing therapy to assess the likelihood of clinical benefit from their prescribed treatment. Blood samples are collected prior to and during the treatment period and analyzed as part of the ongoing development of thealgorithm.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 10000 (estimated)
- First submitted
- 11 Aug 2019
- Start date
- 1 Oct 2019
- Primary completion date
- 1 Oct 2029
- Lead sponsor
- OncoHost Ltd.
- Diseases
- Melanoma, Lung cancer
- NCT number
- NCT04056247
What you commit to
- Study type: Observational
- Planned participants: 10000
- From 1 Oct 2019 to the primary completion date, 1 Oct 2029
- 41 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent and/or other active malignancy that has required systemic treatment within 2 years of first dose of study drug
Other illness
- Generalized impairment or mental incompetence that would render the patient unable to understand his/her participation in the study.
Who the study is looking for
- Provision of informed consent prior to any study-specific procedures.
- Male or female aged at least 18 years.
- ECOG PS - 0/1-2
- Normal hematologic, renal and liver function:
- Absolute neutrophil count higher than 1500/mm3
- Platelets count higher than 100,000/mm3
- haemoglobin higher than 9 g/dL
- Creatinine concentration ≤1.4 mg/dL, or creatinine clearance higher than 40 mL/min
- Total bilirubin lower than 1.5 mg/dL, ALT and AST levels ≤ 3 times above the upper normal limit.
- At least one measurable lesion in order to enable the assessment of the response (except for stage IIIb-d malignant melanoma patients).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (41)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Asklepois Coordinator of this site? Confirm its status | Gauting | Germany | Unknown status |
| Thoraxklinik Heidelberg gGmbH Coordinator of this site? Confirm its status | Heidelberg | Germany | Unknown status |
| 044 Hospital Universitario Virgen Macarena Coordinator of this site? Confirm its status | Seville | Spain | Unknown status |
| Aberdeen Royal Infirmary Coordinator of this site? Confirm its status | Aberdeen | United Kingdom | Unknown status |
| Royal Bournemouth General Hospital Coordinator of this site? Confirm its status | Bournemouth | United Kingdom | Unknown status |
| Bradford Teaching Hospitals Coordinator of this site? Confirm its status | Bradford | United Kingdom | Unknown status |
| Cheltenham General Hospital Coordinator of this site? Confirm its status | Cheltenham | United Kingdom | Unknown status |
| Withybush Hospital Coordinator of this site? Confirm its status | Haverfordwest | United Kingdom | Unknown status |
| Mount Vernon Cancer Centre Coordinator of this site? Confirm its status | Northwood | United Kingdom | Unknown status |
| The Shrewsbury and Telford Hospital Coordinator of this site? Confirm its status | Shrewsbury | United Kingdom | Unknown status |
| South Tyneside Coordinator of this site? Confirm its status | South Shields | United Kingdom | Unknown status |
| Lister Hospital Coordinator of this site? Confirm its status | Stevenage | United Kingdom | Unknown status |
| Sunderland Royal Hospital Coordinator of this site? Confirm its status | Sunderland | United Kingdom | Unknown status |
| Swansea Bay UHB Singleton Hospital Coordinator of this site? Confirm its status | Swansea | United Kingdom | Unknown status |
| Torbay Hospital Coordinator of this site? Confirm its status | Torquay | United Kingdom | Unknown status |
| Haemek Medical Center Coordinator of this site? Confirm its status | Afula | Israel | Unknown status |
| Barzilai Medical Center Coordinator of this site? Confirm its status | Ashkelon | Israel | Unknown status |
| Soroka Medical Center Coordinator of this site? Confirm its status | Beersheba | Israel | Unknown status |
| Shamir Medical Center Coordinator of this site? Confirm its status | Be’er Ya‘aqov | Israel | Unknown status |
| Bnai Zion Medical Center Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Rambam Medical Center Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Hadassah Medcial Center Coordinator of this site? Confirm its status | Jerusalem | Israel | Unknown status |
| Meir Medical Center Coordinator of this site? Confirm its status | Kfar Saba | Israel | Unknown status |
| Rabin Medical Center Coordinator of this site? Confirm its status | Petah Tikva | Israel | Unknown status |
| Kaplan Medical Center Coordinator of this site? Confirm its status | Rehovot | Israel | Unknown status |
| Sourasky Medical Center Coordinator of this site? Confirm its status | Tel Aviv | Israel | Unknown status |
| Assuta Medical Cetner Coordinator of this site? Confirm its status | Tel Aviv | Israel | Unknown status |
| Sheba Medical Center Coordinator of this site? Confirm its status | Tel Aviv | Israel | Unknown status |
| Sheba medical center Coordinator of this site? Confirm its status | Tel HaShomer | Israel | Unknown status |
| Birmingham VAHCS Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Roswell Park Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| Helen Nassif Community Cancer Center Coordinator of this site? Confirm its status | Cedar Rapids | United States | Unknown status |
| West Clinic Coordinator of this site? Confirm its status | Germantown | United States | Unknown status |
| Michael E. DeBakey VA Medical Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Mayo Clinic Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| University of Miami Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Rutgers Cancer Institute Coordinator of this site? Confirm its status | New Brunswick | United States | Unknown status |
| Florida Cancer Specialist and Research Institute Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Protean Biodiagnosics Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Northwest Community Healthcare Coordinator of this site? Confirm its status | Rolling Meadows | United States | Unknown status |
| 151-Christus Health St. Michael Coordinator of this site? Confirm its status | Texarkana | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.