NCT04064294Completed
Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With HMG-CoA Reductase Inhibitors
Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With Statins
Source: ClinicalTrials.gov · Last updated 11 Apr 2025
Brief summary (registry, in English)
In this study, the investigators will examine the association of statin use and dyskinesia in a convenience sample Parkinson's disease patients in the Veterans Administration Health Care System.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 93 (actual)
- First submitted
- 19 Aug 2019
- Start date
- 22 Aug 2019
- Primary completion date
- 31 Mar 2024
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Parkinson disease
- NCT number
- NCT04064294
What you commit to
- Study type: Observational
- Participants enrolled: 93
- From 22 Aug 2019 to the primary completion date, 31 Mar 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of drugs that may affect parkinsonism or dyskinesia:
- dopamine receptor blocking medications
- depakote
- lithium
- amiodarone
- tetrabenazine
- metoclopramide
- dronabinol
- and illicit drugs such as marijuana (THC)
- cocaine
- methamphetamine
- Statins other than simvastatin or lovastatin, atorvastatin ie. fluvastatin (rationale is that while all other statins are thought to not cross the blood brain barrier well, the central nervous system penetrating nature of others is not perfectly clear and could confound results)
Other illness
- Significant cognitive impairment as measured by the Montreal Cognitive Assessment score of \< 18
- Subjects with unstable medical or psychiatric conditions (including hallucinations).
- History of unstable medical conditions (i.e. active cardiac disease, recent unwellness, surgery etc.)
Other
- Deep Brain stimulation
- Unable to stand for 1 minute intervals, or sensory deficits in the feet
Who the study is looking for
- Parkinson's Disease
- Age diagnosed with Parkinson's Disease greater than or equal to 50 years
- Treatment with levodopa greater than or equal to 5 years
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oregon Health Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| VA Portland Health Care System, Portland, OR Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| VA Puget Sound Health Care System Seattle Division, Seattle, WA Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.