NCT04068844Completed
Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Source: ClinicalTrials.gov · Last updated 3 Jun 2026
Brief summary (registry, in English)
The global objective of this study is to determine the mechanisms of exercise intolerance and dyspnea on exertion (DOE) in patients with HFpEF and based on this pathophysiology, test whether specific exercise training programs (whole body vs single leg) will result in improved exercise tolerance.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 93 (actual)
- First submitted
- 22 Aug 2019
- Start date
- 1 Aug 2019
- Primary completion date
- 1 Aug 2025
- Lead sponsor
- University of Texas Southwestern Medical Center
- Diseases
- Heart failure
- NCT number
- NCT04068844
What you commit to
- Study type: Interventional
- Participants enrolled: 93
- From 1 Aug 2019 to the primary completion date, 1 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- PDE5 inhibitor use
Other illness
- Severe valvular disease
Age
- age \< 60 years
Other
- BMI \> 50 kg/m2
- Severe COPD
- CKD 4 or higher
- Contra-indication to MRI.
Who the study is looking for
- signs and symptoms of heart failure
- an ejection fraction \> 0.50
- objective evidence of diastolic dysfunction
Age in the registry: 60 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Institute for Exercise and Environmental Medicine Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.