Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung Cancer

Prior treatment

• Prior radiation therapy targeting the same area for which radiation treatment is being planned
• Patients who undergo sublobar resection but are unable to undergo appropriate N1 and N2 lymph node sampling

Other illness

• Any condition which, in the investigator?s opinion, deems the patient unable to participate in enrollment

Other

• Contraindication to SBRT
  • This includes the inability to cooperate with any aspect of SBRT such as the inability to lie still and breath reproducibly
• Pregnant or nursing female patients
• Unwilling or unable to follow protocol requirements

• Have an Eastern Cooperative Oncology Group (ECOG) performance status =\< 2
• Has completed curative-intent surgical resection of lung primary with pathologic diagnosis of NSCLC disease, with pathology to include at least 1 of the following:
  • Close (\<=2 mm) or Positive surgical margin (R1/R2) or pathologic N2 disease (with or without extracapsular extension \[ECE\])
• Anatomic pulmonary resection (lobectomy or pneumonectomy) preferred, although sublobar resection is allowed at the discretion of the treating surgeon. Systemic lobe-specific nodal sampling is required. A minimum of 3 N2 stations must be sampled. Selective lymph node dissection should be completed for patients with known N2 disease
• Women of child-bearing potential must agree to use adequate contraceptive methods (e.g., hormonal or barrier method of birth control; abstinence)
• Patient or legal representative must be willing and able to participate in protocol requirements, including pre- and post-treatment survey evaluations and clinical assessments
• Patient or legal representative must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure