NCT04081636Completed
Prostate Biopsy, Transrectal vs. Transperineal: Efficacy and Complications
Prospective, Randomized Study Comparing Transperineal and Transrectal Prostate Biopsy Efficacy and Complications (ProBE-PC Trial)
Source: ClinicalTrials.gov · Last updated 23 Dec 2025
Brief summary (registry, in English)
This study evaluates the difference between 2 prostate biopsy methods, transrectal (through the rectal wall) and transperineal (through the skin) needle biopsy. Men who are in need of prostate biopsy due to clinical suspicions of prostate cancer will be randomly assigned (1:1) to either transrectal or transperineal approach. This research study will scientifically determine if one biopsy method is better than the other in reducing complications and improving cancer detection.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 840 (actual)
- First submitted
- 5 Sept 2019
- Start date
- 2 Sept 2019
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- Albany Medical College
- Diseases
- Prostate cancer, Childhood cancers
- NCT number
- NCT04081636
What you commit to
- Study type: Interventional
- Participants enrolled: 840
- From 2 Sept 2019 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with no access to rectum (due to previous rectal surgery)
Other illness
- Any abnormalities of the perineal skin (e.g. infection)
Other
- Patients whose procedure requires sedation or general anesthesia
Who the study is looking for
- All patients who are scheduled to undergo prostate biopsy for suspected prostate cancer as part of their regular medical care
- Either with or without an MRI
Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Albany Medical College Coordinator of this site? Confirm its status | Albany | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.