NCT04084145Active, not recruiting
National Unified Renal Translation Research Enterprise - Chronic Kidney Disease
Source: ClinicalTrials.gov · Last updated 3 Apr 2025
Brief summary (registry, in English)
Chronic Kidney Disease (CKD) affects around 10% of the adult population and is associated with an increased risk of heart attack, stroke and end stage kidney disease (ESKD). This study aims to better predict who is most likely to progress to ESKD using previously identified risk factors and novel biomarkers in blood and urine samples, along with kidney biopsy tissue. Resources can then be directed to those most at risk of disease progression and other associated conditions such as heart attack and stroke, while those at lower risk can be offered less frequent monitoring.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 3004 (actual)
- First submitted
- 5 Mar 2019
- Start date
- 27 Jul 2016
- Primary completion date
- 31 Dec 2032
- Lead sponsor
- University of Nottingham
- Diseases
- Chronic kidney disease
- NCT number
- NCT04084145
What you commit to
- Study type: Observational
- Participants enrolled: 3004
- From 27 Jul 2016 to the primary completion date, 31 Dec 2032
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recipient of a solid organ transplant
- Previous unilateral nephrectomy or partial nephrectomy
- Recipient of a solid organ transplant
Other illness
- No other major illnesses except for hypertension and type 2 diabetes mellitus (50 participants will have diabetes but no CKD)
Lab values
- Estimated GFR\<60ml/min/1.73m2 in previous 12 months or last available result
- Urine albumin to creatinine ratio \>3mg/mmol in previous 12 months or last available result
Age
- Age over 18 years of age
Other
- Expected survival less than 1 year (in the opinion of local investigators)
- Acute kidney injury within 3 months of recruitment
- Major Acute Cardiovascular Event (MACE) within 3 months of recruitment
- Participants without CKD - controls Inclusion criteria
- Willing to participate in one study visit
- Able to give informed consent and participate in study procedures
- No evidence of CKD
- Expected survival less than 1 year (in the opinion of local investigators)
Who the study is looking for
- Age Over 18 years of age
- Estimated GFR 59-15ml/min/1.73m² or eGFR \>60ml/min/1.73m² and urine albumin to creatinine ratio \>30mg/mmol
- Seen at least once in a Nephrology Clinic
- Willing to participate in two study visits
- Able to give informed consent and participate in study procedures
Criteria the registry did not label
- Participants with CKD
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Royal Derby Hospital Coordinator of this site? Confirm its status | Derby | United Kingdom | Unknown status |
| Salford Royal Hospital Coordinator of this site? Confirm its status | Salford | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.