NCT04103593Completed
Functional Interval Training for Veterans Exercising Through Telehealth.
Effects of 12-weeks of High-intensity Resistance Aerobic Circuit Exercise Training on Epigenetic Aging and Inflammation in Older HIV-infected Veterans
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
Most Veterans living with HIV are 50 years of age or older and can expect to live more than 20 years longer with HIV medication. However, despite this success, Veterans living with HIV are more likely to have age-related diseases and loss of fitness and muscle that place them at increased risk for disability. This is a major priority for the VHA, the largest provider of HIV care in the United States. The goal of this study is to test a circuit exercise program in Veterans living with HIV that is designed to slowdown the aging process. The exercise program will be widely available by Video Teleconferencing (VTEL) and does not require stationary exercise equipment, making it widely accessible. This research will help reach the goal for Veterans to preserve their quality of life and ability to function independently. Novel findings will strengthen strategies to maintain life-long fitness through a personalized exercise prescription.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 89 (actual)
- First submitted
- 23 Sept 2019
- Start date
- 10 Mar 2020
- Primary completion date
- 27 Sept 2024
- Lead sponsor
- VA Office of Research and Development
- Diseases
- HIV
- NCT number
- NCT04103593
What you commit to
- Study type: Interventional
- Participants enrolled: 89
- From 10 Mar 2020 to the primary completion date, 27 Sept 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving treatment for cancer except skin cancer (within 3 months)
- Use of systemic steroids (testosterone or glucocorticoids) or growth hormone (within 6 months)
Other illness
- History of AIDS defining illnesses (within 6 months; CDC Criteria)
- Myocardial infarction (within 3 months)
- Exertional or unstable angina (current chest pain that limits activity)
- Severe congestive heart failure (EF \< 20% in last year or NYHA Classification III or IV)
- Uncontrolled hypertension (SBP \>180 \&/or DBP \> 110 mm Hg)
- Screening EKG with ischemia, complex arrhythmia, or high-grade block (per Minnesota Code)
- Peripheral vascular disease with claudication
- Neurologic disease limiting ambulation (requiring assist device)
- End stage liver disease (decompensated liver disease)
- Chronic renal failure (requiring dialysis)
- Severe pulmonary disease (home O2, admission for dyspnea or pneumonia within 1 month)
- Dementia (based on Evaluation to Consent)
- Past medical history of COPD or emphysema AND mMRC score =4
Lab values
- Therapy with beta blockers or non-dihydropyridine calcium channel blocker (within 1 month)
- Poorly controlled DM within prior 1 month (FBS\>180 mg/dl, RBS \> 299 mg/dl, or HbA1C \> 10)
Other
- Severe arthritis limiting ambulation
- Signs or symptoms of any medical comorbidity that would preclude exercise testing or training
- Exercise on routine basis (structured aerobic exercise \> 3 times per week) within 1 month
Who the study is looking for
- Veteran living with HIV and under care at VAMC
- 50 years of age and older
- Stable antiretroviral therapy (same ARV medications within 3 months)
- At least one HIV-1 PCR \< 20 c/ml (viral load) within prior 6 months
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Atlanta VA Medical and Rehab Center, Decatur, GA Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Salem VA Medical Center, Salem, VA Coordinator of this site? Confirm its status | Salem | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.