NCT04106219Active, not recruitingPhase 1
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
A Phase 1 Study of Aurora Kinase A Inhibitor LY3295668 Erbumine as a Single Agent and in Combination in Patients With Relapsed/Refractory Neuroblastoma
Source: ClinicalTrials.gov · Last updated 21 Aug 2026
Brief summary (registry, in English)
The reason for this study is to see if the study drug LY3295668 erbumine is safe in participants with relapsed/refractory neuroblastoma.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 71 (estimated)
- First submitted
- 25 Sept 2019
- Start date
- 11 Jun 2020
- Primary completion date
- 13 Apr 2022
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Neuroblastoma, Childhood cancers
- NCT number
- NCT04106219
- EU CT number
- 2024-512102-25-00
- EudraCT number
- 2019-001042-18
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 71
- From 11 Jun 2020 to the primary completion date, 13 Apr 2022
- 16 sites in 9 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants must not have had an allogeneic hematopoietic stem cell, bone marrow, or solid organ transplant.
- Participants must not have had prior aurora kinase inhibitor exposure.
Other illness
- Participants must not have a serious active disease other than neuroblastoma.
- Participants must not have a condition affecting absorption.
- Participants must not have a known allergy to the study treatment.
- Participants must not have symptomatic human immunodeficiency virus (HIV) infection or symptomatic activated/reactivated hepatitis A, B, or C.
Other
- Participants must not have untreated tumor that has spread to the brain or spinal cord.
Who the study is looking for
- Participants must have relapsed/refractory neuroblastoma and have active disease in at least one site: bone, bone marrow or soft tissue. Participants must be able to submit an archival sample of tissue.
- Participants must be able to swallow capsules.
Age in the registry: 2 years to 21 years · Sex: All · Does not accept healthy volunteers
Sites (16)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Perth Children's Hospital Coordinator of this site? Confirm its status | Perth | Australia | Unknown status |
| UZ Gent Coordinator of this site? Confirm its status | Ghent | Belgium | Unknown status |
| Universitätsklinikum Köln Coordinator of this site? Confirm its status | Cologne | Germany | Unknown status |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Centre Leon Berard Coordinator of this site? Confirm its status | Lyon | France | Unknown status |
| Institut Curie Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Alder Hey Children's Hospital Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Unknown status |
| Istituto Nazionale dei Tumori Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| National Cancer Center Hospital Coordinator of this site? Confirm its status | Chuo Ku | Japan | Unknown status |
| Children's Hospital Colorado Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Dana-Farber Cancer Institute Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| University of Chicago Comer Children's Hospital Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Cincinnati Childrens Hospital Medical Center Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Texas Childrens Hospital Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Children's Hospital of Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| UCSF Medical Center at Mission Bay Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.