NCT04106830Recruiting
Clinical and Imaging Cohort of Neuroinflammation Diseases in China (CLUE)
Prospective Cohort Study of cLinical and Imaging Patterns of neUroinflammation disEases (CLUE)
Source: ClinicalTrials.gov · Last updated 15 Jun 2026
Brief summary (registry, in English)
CLUE is a prospective study to assess structural and functional changes of the brain, spinal cord, and optic nerve, as well as the inflammatory environment in patients with neuroinflammatory and demyelinating diseases. Participants will receive magnetic resonance (MR) techniques including DIR, DKI, QSM, Rs-fMRI, conventional sequences (T1WI/T2WI/FLAIR), and the MR metabolic SPICE sequence, and will be followed up for one year using 3T MRI. In addition, participants will receive a one-time baseline examination including T1WI, T2WI, FLAIR, and SWI sequences on 7T MRI, as well as PET-MRI.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1000 (estimated)
- First submitted
- 25 Sept 2019
- Start date
- 1 Jan 2019
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Beijing Tiantan Hospital
- Diseases
- Multiple sclerosis
- NCT number
- NCT04106830
What you commit to
- Study type: Observational
- Planned participants: 1000
- From 1 Jan 2019 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patients for whom MRI is contra-indicated
- Patients included in an ongoing clinical trial where the product is blinded
Who the study is looking for
- 16-75
- Diagnosis of neuroinflammatory and demyelination disease
- Availability of demographic and clinical data at the time disease onset
- Informed written consent obtained from the patient, and/or patient's parent(s), and/or legal representative. Assent, if old enough to grant, will be obtained from all patients under the age of 16 years.
Age in the registry: 16 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Tiantan Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.