NCT04111094Completed
DKK3 for Prognosis and Monitoring of GFR Decline in Heart Failure
Urinary Dickkopf-3 for Prognosis and Monitoring of Glomerular Filtration Rate Decline in Patients With Heart Failure
Source: ClinicalTrials.gov · Last updated 9 May 2024
Brief summary (registry, in English)
The individual course of chronic kidney disease (CKD) may vary, and improved methods for identifying which patients will experience estimated glomerular filtration rate (eGFR) decline are needed. Recently, urinary dickkopf-3 (DKK3) has been proposed to predict eGFR decline in patients with CKD, independent of presence of albuminuria. The investigators sought to examine the association between changes in DKK3 levels and eGFR decline in patients with heart failure (HF).
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 290 (actual)
- First submitted
- 27 Sept 2019
- Start date
- 14 Oct 2019
- Primary completion date
- 21 Jan 2023
- Lead sponsor
- University of Giessen
- Diseases
- Chronic kidney disease, Heart failure
- NCT number
- NCT04111094
What you commit to
- Study type: Observational
- Participants enrolled: 290
- From 14 Oct 2019 to the primary completion date, 21 Jan 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- likelihood of receiving advanced therapy (mechanical circulatory assist device/cardiac transplant)
Other illness
- active tumor disease
- inflammatory or autoimmune disease requiring systemic immunosuppressive treatment
- clinically apparent infections
Lab values
- CKD with estimated GFR \<20 ml/min/1.73 m2 (2012 CKD-EPI equation)
Other
- CKD with extracorporeal or peritoneal ultrafiltration due to diuretic-resistant fluid overload
- recipients of solid-organ transplants
- anticipated life expectancy of \<12 months
- pregnancy or possibility of pregnancy in the next 12 months
Who the study is looking for
- Outpatients ≥18 years of age with diagnosed HF or diabetes or hypertension
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Clinic Giessen and Marburg - Campus Giessen Coordinator of this site? Confirm its status | Giessen | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.