NCT04118998Active, not recruiting
Progressive Abduction Loading Therapy
Progressive Abduction Loading Therapy: A Phase IIb Stroke Rehabilitation Trial With Longitudinal Tracking
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
This study attempts to minimize the development of a common movement impairment following stroke known as "flexion synergy" that makes it extremely difficult to reach outward with the arm. Participants with acute/subacute stroke will receive one of two study interventions in addition to prescribed therapies in both inpatient rehabilitation and day-rehab. Participants will be followed for 1 year.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 86 (estimated)
- First submitted
- 23 Sept 2019
- Start date
- 27 Aug 2021
- Primary completion date
- 7 Jul 2026
- Lead sponsor
- Northwestern University
- Diseases
- Stroke
- NCT number
- NCT04118998
What you commit to
- Study type: Interventional
- Planned participants: 86
- From 27 Aug 2021 to the primary completion date, 7 Jul 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Premorbid and persistent disability or motor impairment of the upper extremities
- Any other chronic neurological condition
- Pain or hypersensitivity limiting motor assessments
Other
- Brainstem and/or cerebellar lesion
- Comorbidity medically contraindicating motor assessments
- Limb edema limiting study motor assessments
Who the study is looking for
- Hemiparesis confined to one side, (CMSA Stage 2 or 3 out of 7)
- Stroke impacting parenchyma of the middle cerebral artery distribution
- Within 90 days post-stroke
- 18 to 85 years old
- No or Mild-to-moderate Aphasia (NIHSS #9 Best Language. = 0 or 1- Describe picture; No or Mild-to-moderate Aphasia)
- No or Mild extinction and inattention (NIHSS 11 Extinction and Inattention. = 0 or 1- No abnormality or Inattention to one modality.)
- Ability to perform a 3-step motor command with the unaffected arm
- Capacity to provide informed consent
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shirley Ryan AbilityLab Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Department of Physical Therapy and Human Movement Sciences Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Northwestern Medicine Marianjoy Rehabilitation Hospital Coordinator of this site? Confirm its status | Wheaton | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.