NCT04120935Recruiting
ALFAOMEGA Master Observational Trial
A Master Protocol Empowering Precision Research in Colorectal Cancer
Source: ClinicalTrials.gov · Last updated 24 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
AlfaOmega has been designed to streamline the study of the co-evolutionary landscape between tumor and host cells in a cohort of CRC patients, with the aim of understanding how their outcomes can be significantly improved (e.g. reduction of their chance of recurrence and survival improval). This clinical resource for integrative clinical data and sample collection will allow the molecular story-telling of CRC metastatic spread along time and space and the selection of appropriate patients for experimentally-driven trials.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 3000 (estimated)
- First submitted
- 18 Sept 2019
- Start date
- 15 Oct 2019
- Primary completion date
- Jun 2026
- Lead sponsor
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Diseases
- Colorectal cancer
- NCT number
- NCT04120935
What you commit to
- Study type: Observational
- Planned participants: 3000
- From 15 Oct 2019 to the primary completion date, Jun 2026
- 19 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any other current malignancy or malignancy diagnosed or relapsed within the past 5 years (other than non-melanomatous skin cancer, stage 0 melanoma in situ, and in situ cervical cancer)
- Known Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) or syphilis infection.
Other
- Patient unable to comply with the study protocol owing to psychological, social or geographical reasons.
Who the study is looking for
- TIER1 written Informed consent.
- Patients ≥18 years of age.
- Previous diagnosis of colorectal cancer, or a strong suspicion of CRC based on clinical and radiological findings.
- In patients with previous diagnosis of CRC availability of diagnostic Formalin-Fixed, Paraffin Embedded (FFPE) blocks (surgical resection and/or tumor biopsies), or at least 10 slides (preferably 20). FFPE tissue blocks are always preferred to slides.
- ECOG Performance status \< 2.
Age in the registry: 18 years to - · Sex: All
Sites (19)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vall d'Hebron Institute of Oncology (VHIO) Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital del Mar - Parc de Salut Mar Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital de Sant Joan Despí - Moises Broggi Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital Moises Broggi Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| INCLIVA - Instituto de Investigatión Sanitaria Coordinator of this site? Confirm its status | Valencia | Spain | Recruiting |
| ASL di Biella - Ospedale degli Infermi Coordinator of this site? Confirm its status | Biella | Italy | Recruiting |
| Istituto di Candiolo, IRCCS Coordinator of this site? Confirm its status | Candiolo | Italy | Recruiting |
| Ospedale Policlinico San Martino Coordinator of this site? Confirm its status | Genova | Italy | Recruiting |
| Fondazione IRCCS - Istituto Nazionale dei Tumori Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| IRCCS Istituto Clinico Humanitas Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Istituto Europeo di Oncologia (IEO) Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Azienda Ospedaliera Universitaria Luigi Vanvitelli Coordinator of this site? Confirm its status | Naples | Italy | Recruiting |
| Azienda Ospedaliero-Universitaria San Luigi Gonzaga Coordinator of this site? Confirm its status | Orbassano | Italy | Recruiting |
| Istituto Oncologico Veneto (IOV) Coordinator of this site? Confirm its status | Padova | Italy | Recruiting |
| Ospedale Santa Maria della Misericordia Coordinator of this site? Confirm its status | Perugia | Italy | Recruiting |
| Azienda Ospedaliero Universitaria Pisana Coordinator of this site? Confirm its status | Pisa | Italy | Recruiting |
| AUSL Della Romagna - Ospedale Santa Maria delle Croci Coordinator of this site? Confirm its status | Ravenna | Italy | Recruiting |
| Azienda Ospedaliera Ordine Mauriziano Coordinator of this site? Confirm its status | Torino | Italy | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.