NCT04126148Active, not recruiting
Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 236 (actual)
- First submitted
- 11 Oct 2019
- Start date
- 4 Jul 2019
- Primary completion date
- 13 Jan 2026
- Lead sponsor
- Matthias Friedrich
- Diseases
- Coronary artery disease
- NCT number
- NCT04126148
What you commit to
- Study type: Observational
- Participants enrolled: 236
- From 4 Jul 2019 to the primary completion date, 13 Jan 2026
- 8 sites in 7 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam.
- Vasoactive medication (e.g. nitro) during the 12 hours prior to the exam Contraindications to adenosine (2nd or 3rd A-V block, sinus node disease, asthma, bronchoconstrictive diseases).
- Acute Coronary Syndrome (ACS), or previous Coronary Artery Bypass Surgery
- Previous myocardial infarction within 1 month
Other illness
- Clinically unstable condition
- Significant or uncontrolled arrhythmia
Other
- ALL participants:
- General MRI contraindications: Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
- Regular nicotine consumption during the last 6 months.
- Patients only
Who the study is looking for
- Healthy Participants
- Age: \> 40y
- No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system.
- CAD Patients
- Age \> 18 y
- Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Flinders Medical Centre Coordinator of this site? Confirm its status | Bedford Park | Australia | Unknown status |
| McGill University Health Center Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Sunnybrook Research Institute Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Cardiovid Clinic Coordinator of this site? Confirm its status | Medellín | Colombia | Unknown status |
| Charité University Hospital Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| Glenfield Hospital Coordinator of this site? Confirm its status | Leicester | United Kingdom | Unknown status |
| Hippokration University Hospital Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| Rhode Island Hospital Coordinator of this site? Confirm its status | Providence | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.