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NCT04127994Completed

Glycemic Variability Comparing Two vs Five Meals in Type 2 Diabetes

Effect on Glycemic Variability, Weight and Oxidative Stress Markers FGF 21 in a Low Calorie Diet of Three Meals Compared With a Conventional Low Calorie Plan of Five Meals in Patients With Type 2 Diabetes With Overweight or Obesity

Source: ClinicalTrials.gov · Last updated 27 Mar 2026

Brief summary (registry, in English)

The frequency of meals is a very important aspect of nutrition, with profound effects on human health and in life expectancy. Excessive energy consumption is totally associated with a significant increase in the incidence of chronic diseases including diabetes. That is why nutritional therapy is recommended for all people with diabetes mellitus type 1 and 2 as an effective complement to your medical treatment. For overweight or obese type 2 diabetic patients, a low-calorie diet along with healthy eating patterns are recommended for weight loss. Similarly, modest body weight decrease may provide clinical benefits in patients, such as improved blood glucose, blood pressure, lipid profile, and others. Data about the role of nutritional habits and energy density being important precursors of obesity and diabetes are well known. On the other hand, data regarding frequency and timing of meals and how these factors relate to corporal weight are not totally understood.

Status (registry)
Completed
Study type
Interventional
Enrollment
50 (actual)
First submitted
11 Sept 2019
Start date
17 Aug 2018
Primary completion date
11 Dec 2023
Lead sponsor
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
NCT number
NCT04127994

What you commit to

  • Study type: Interventional
  • Participants enrolled: 50
  • From 17 Aug 2018 to the primary completion date, 11 Dec 2023
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Lab values

  • HbA1c \>9%

Age

  • \>10 years of evolution

Other

  • Obesity 3rd grade
  • DM 1
  • Hospitalization in the last 3 months
  • Pregnancy

Who the study is looking for

  • Oral hypoglycemic agents
  • HbA1c \<9%
  • Less than 10 years of evolution
  • Diabetes Mellitus type 2
  • Overweight or obese
  • Age 40-70 years
  • BMI ≥25 to \< 40 kg/m

Age in the registry: 40 years to 70 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán ''INCMNSZ''
Coordinator of this site? Confirm its status
Mexico CityMexicoUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.