NCT04130646Completed
Noninvasive VNS to Facilitate Excitability in Motor Cortex
Combining Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) With Transcranial Magnetic Stimulation (TMS) to Enhance Cortical Excitability
Source: ClinicalTrials.gov · Last updated 20 Apr 2025
Brief summary (registry, in English)
Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity. We investigate whether combination of TMS and taVNS is more effective at motor cortex excitability than either modality alone.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 12 (actual)
- First submitted
- 30 Sept 2019
- Start date
- Mar 2020
- Primary completion date
- Jun 2023
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Stroke
- NCT number
- NCT04130646
What you commit to
- Study type: Interventional
- Participants enrolled: 12
- From Mar 2020 to the primary completion date, Jun 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- currently taking seizure reducing medications
- currently taking psychotropic medications
- any psychotropic medication taken within 5 half-lives of procedure time
- abuse or dependence of drugs (excluding nicotine and caffeine)
- currently taking medications that lower the seizure threshold
- taking any of the stimulants, thyroid medication, or steroids
Other illness
- active psychiatric or neurological disorders
- history of CNS disease, concussion, overnight hospitalization, or other neurologic sequelae, tumors, seizures, frequent or severe headaches
- history of seizure or seizure disorder
Age
- Pregnant females and children under the age of 18 will be excluded for safety reasons
Other
- no TMS-induced motor cortex excitability changes in response to 20Hz motor cortex rTMS
- metal implanted above the neck
- implanted devices/ferrous metal of any kind
- inability to determine motor threshold.
- No vulnerable populations or special classes of subjects will be considered for participation.
Who the study is looking for
- Age 18-80
- endorsing good health
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.