Study of Cabozantinib Efficacy, Safety and Tolerability in Metastatic Renal Carcinoma in Aged Fragile Patients: CABOMAYOR Study

Prior treatment

• Previous treatment for mRCC.
• Radiation therapy for bone metastasis within 2 weeks, any other external radiation therapy within 4 weeks before inclusion.
• Known brain metastases or cranial epidural disease unless adequately treated and stable for at least 3 months before inclusion.
• Chronic treatment with corticosteroids or other immunosuppressive agents
• Uncontrolled, significant intercurrent or recent illness including, but not limited to, the following conditions: Cardiovascular disorders, Gastrointestinal (GI) disorders including those associated with a high risk of perforation or fistula formation, Clinically significant hematuria, hematemesis, or hemoptysis of \> 0.5 teaspoon of red blood, or other history of significant bleeding (eg, pulmonary hemorrhage) within 3 months before inclusion, Cavitating pulmonary lesion(s) or known endobronchial disease manifestation and/or Lesions invading major pulmonary blood vessels.
• Major surgery within 2 months before inclusion.
• Previously identified allergy or hypersensitivity to components of the study treatment formulation.
• Diagnosis of another malignancy within 2 years before inclusion, except for superficial skin cancers, or localized, low grade tumors deemed cured and not treated with systemic therapy.

Lab values

• Concomitant anticoagulation at therapeutic doses with oral anticoagulants or platelet inhibitors or low molecular weight heparins (LMWH).
• Corrected QT interval calculated by the Fridericia formula (QTcF) \> 500 msec within 10 days before inclusion.

Other

• Inability to swallow tablets or capsules.

• Documented histological or cytological diagnosis of renal cell cancer.
• Measurable disease per RECIST 1.1 as determined by the investigator.
• Metastatic disease.
• Patient must have signed the informed consent document.
• Capable of understanding and complying with the protocol requirements.
• Eastern Cooperative Oncology Group Performance Status (ECOG-PS) 0-2.
• Patients aged \>70 years old with Society of Geriatric Oncology (SIOG) defined fragile population or patients \>75 years with or without SIOG defined fragility.
• No previous treatment for Metastatic Renal Cell Carcinoma (mRCC)
• Adequate organ function based on standard laboratory tests including haematology, serum chemistry, lipids, coagulation, thyroid function, and urinalysis.
• Sexually active fertile subjects and their partners must agree to use medically accepted methods of contraception (eg, barrier methods, including male condom, female condom, or diaphragm with spermicidal gel) during the course of the study and for 4 months after the last dose of study treatment.