NCT04134754Recruiting
Carbon Dioxide (CO2) Chemosensitivity and SUDEP
The Role of Central CO2 Chemosensitivity in Postictal Respiratory Depression and SUDEP
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
The purpose of this research study is to better understand what causes Sudden Unexpected Death in Epilepsy (SUDEP). This study will enroll subjects from the University of Iowa Hospitals and Clinics (UIHC) Epilepsy Monitoring Unit (EMU) and Epilepsy Clinics. The investigators will analyze the effects of seizures on breathing, on the cardiovascular system, and on arousal. The investigators are studying these effects because some cases of SUDEP might be due, in part, to an inability to wake up or sense elevated carbon dioxide (CO2) levels when breathing is impaired. Subjects will be followed for ten years after enrollment to monitor their health.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 335 (estimated)
- First submitted
- 8 Oct 2019
- Start date
- 12 Dec 2019
- Primary completion date
- 1 Oct 2029
- Lead sponsor
- University of Iowa
- Diseases
- Epilepsy
- NCT number
- NCT04134754
What you commit to
- Study type: Interventional
- Planned participants: 335
- From 12 Dec 2019 to the primary completion date, 1 Oct 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of uncontrolled cardiac, pulmonary, or hepatic disease.
- Progressive or uncontrolled neurologic disease unrelated to epilepsy.
- Other comorbid condition that may influence the safety or feasibility of HCVR testing.
Other
- Current opioid use.
- Women of child-bearing potential who are pregnant or capable of becoming pregnant (e.g. sexual activity within the past 21 days without a highly effective form of birth control or positive urine pregnancy test).
- Limited decision-making capacity and absence of a qualified representative.
Who the study is looking for
- The subject is between 18 and 99 years of age.
- Confirmed or suspected epilepsy.
- Admission to the EMU for spell characterization (EMU group) or undergoing care in the University of Iowa Health Care Epilepsy Clinic.
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Iowa Hospitals and Clinics Coordinator of this site? Confirm its status | Iowa City | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.