NCT04149288Active, not recruiting
Olive Oil Polyphenols and Cardiovascular Health Biomarkers
Source: ClinicalTrials.gov · Last updated 29 Jan 2026
Brief summary (registry, in English)
The purpose of this research is to investigate whether consuming two different kinds of olive oil will change risk factors related to cardiovascular disease, including levels of good and bad cholesterol, levels of inflammation, and levels of gene expression.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 44 (estimated)
- First submitted
- 30 Sept 2019
- Start date
- 6 Oct 2021
- Primary completion date
- 22 Aug 2026
- Lead sponsor
- University of California, Davis
- Diseases
- Obesity
- NCT number
- NCT04149288
What you commit to
- Study type: Interventional
- Planned participants: 44
- From 6 Oct 2021 to the primary completion date, 22 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Documented chronic diseases including diabetes, thyroid disease, kidney disease, metabolic syndrome, active cancer, previous cardiovascular events, history of gastric bypass or other GI issues related to fat absorption
- Smoker or living with a smoker, illicit drug use, consuming \>1 alcoholic drink/day, vaporizer and/or electronic cigarette use
- Taking prescription lipid medications or supplements that may affect lipoprotein metabolism, \>1 g of fish oil/day, antioxidant supplements, cannabidiol (CBD) oil
Other illness
- Allergy to olives, inability to tolerate gluten or multiple allergies/intolerances that would significantly limit food intake
Lab values
- History of dyslipidemia or abnormal blood glucose levels (total cholesterol \>240 mg/dL, elevated fasting blood glucose levels \>125 mg/dL)
Other
- Adults unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant or lactating women, women planning to become pregnant in the next two months and prisoners will be specifically excluded
- Extreme dietary or exercise patterns
- Recent weight fluctuations (\>10% in the last 6 months)
- Taking exogenous hormones (e.g. hormonal birth control)
- Poor venous access
- Unwillingness to comply with study protocol
Who the study is looking for
- Generally healthy male and female subjects within the range of 20-45 years of age and BMI range of 18.5-29.9 kg/m2 for the healthy weight/overweight group and ≥ 30 kg/m2 for the obese group will be recruited.
Age in the registry: 20 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ragle Human Nutrition Center Coordinator of this site? Confirm its status | Davis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.