NCT04150718Completed
Role of Slow-wave Activity and Plasticity in MDD
Investigating the Role of Slow-wave Activity as a Marker of Impaired Plasticity in Major Depressive Disorder
Source: ClinicalTrials.gov · Last updated 27 Dec 2024
Brief summary (registry, in English)
The hypothesis underlying this proposal is that deficits of synaptic plasticity underlie the slow-wave activity (SWA) abnormalities observed n major depressive disorder (MDD), and that manipulating SWA may serve to circumvent these deficits by facilitating an increase in synaptic strength via the inhibition of synaptic down-scaling, thereby improving plasticity and mood.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 77 (actual)
- First submitted
- 7 Oct 2019
- Start date
- 4 Mar 2020
- Primary completion date
- 31 Mar 2023
- Lead sponsor
- University of Pennsylvania
- Diseases
- Depression
- NCT number
- NCT04150718
What you commit to
- Study type: Interventional
- Participants enrolled: 77
- From 4 Mar 2020 to the primary completion date, 31 Mar 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current or prior medical condition
- travel beyond 2 time zones in the 2 months before study
Other illness
- History of stroke, epilepsy, brain aneurysm clip or head injury causing unconsciousness
- Implanted devices (i.e. aneurysm clip or cardiac pacemaker)
- Sleep disorders other than insomnia
- History of bipolar disorder, delirium, dementia, amnestic disorder, schizophrenia and other psychotic disorders
- No history of depression for the control group.
- Lifetime history of electroconvulsive therapy
Other
- For women, pregnancy will exclude participation.
- Unwillingness to refrain from using alcohol or caffeine during the study
Who the study is looking for
- Age: 25-50
- Right handed
- English speaking
- Normal cognition
- Normal or corrected-to-normal vision and hearing
- Current depression as assessed on the SCID and Hamilton Rating Scale for Depression
- Stable, normally-time sleep-wake cycles as determined by interview, 1-week daily sleep log and 1-week wrist actigraphy evidence
Age in the registry: 25 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania, Department of Psychiatry Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.