NCT04156893RecruitingPhase 1/2
RH Genotype Matched RBC Transfusions
RH Genotype Matched Red Cell Transfusions for Patients With Sickle Cell Disease
Source: ClinicalTrials.gov · Last updated 27 Apr 2026
Brief summary (registry, in English)
To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 35 (estimated)
- First submitted
- 6 Nov 2019
- Start date
- 30 Jan 2020
- Primary completion date
- Apr 2029
- Lead sponsor
- Children's Hospital of Philadelphia
- Diseases
- Sickle cell disease
- NCT number
- NCT04156893
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 35
- From 30 Jan 2020 to the primary completion date, Apr 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Rare RH genotype that would preclude identification of sufficient RBC units
- Antigen negative requirements due to alloimmunization that would preclude identification of sufficient RBC units
- Alloimmunized to D antigen
- Rh alloimmunized patients for whom providing RH genotype matched blood would expose the patient to an antigen that would not be consistent with standard of care and blood bank protocols
- Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures
Who the study is looking for
- Subjects age \>6 months
- Diagnosis of SCD, all genotypes
- Require a period of chronic red cell transfusion therapy
- Subject/parental/guardian permission (informed consent) and if appropriate, child assent
Age in the registry: 6 months to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Children's Hospital of Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
Related publications
- Red cell antigen exposures in patients with sickle cell disease receiving transfusion from Black and Hispanic donors.Blood Red Cells Iron · 2026 · PMID 42376265
This page is information, not medical advice. Discuss any trial with your doctor.