NCT04156906CompletedEarly phase 1
RHD Genotype Matched Red Cells for Anti-D
RH Genotype Matched Red Cells for Patients With Sickle Cell Disease and Anti-D
Source: ClinicalTrials.gov · Last updated 2 May 2025
Brief summary (registry, in English)
This is a pilot study to evaluate the feasibility and safety of providing RH genotype matched D+ Red Blood Cells (RBCs) to chronically transfused patients with sickle cell disease (SCD) who type D+ but have formed anti-D and are currently transfused with D- RBC (Red Blood Cell) units.
- Status (registry)
- Completed
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 5 (actual)
- First submitted
- 6 Nov 2019
- Start date
- 8 Jul 2020
- Primary completion date
- 4 Mar 2024
- Lead sponsor
- Children's Hospital of Philadelphia
- Diseases
- Sickle cell disease
- NCT number
- NCT04156906
What you commit to
- Study type: Interventional · Early phase 1
- Participants enrolled: 5
- From 8 Jul 2020 to the primary completion date, 4 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Rare RH genotype that would preclude sufficient RBC units
- Antigen negative requirements due to alloimmunization that would preclude sufficient RBC units
Who the study is looking for
- Subjects age \> 8 years old
- Diagnosis of SCD, all genotypes
- Require chronic red cell transfusion therapy
- History of anti-D
- RH genotype predicts D+ expression
Age in the registry: 8 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Children's Hospital of Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
Related publications
- Red cell antigen exposures in patients with sickle cell disease receiving transfusion from Black and Hispanic donors.Blood Red Cells Iron · 2026 · PMID 42376265
This page is information, not medical advice. Discuss any trial with your doctor.