LITT Followed by Hypofractionated RT for Recurrent Gliomas

Prior treatment

• Patients that are not surgical candidates for stereotactic biopsy or laser ablation
• Patients with impaired cardiac function or clinically significant cardiac diseases, including any of the following:
  • History or presence of serious uncontrolled ventricular or significant arrhythmias.
  • Any of the following within 6 months prior to registration: myocardial infarction, severe/unstable angina, coronary artery bypass graft, congestive heart failure, cerebrovascular accident, transient ischemic attack , pulmonary embolism

Other

• Infratentorial tumor or evidence of leptomeningeal spread
• Inability to undergo a MRI
• Pregnant or breast-feeding women

• Patients with history of a WHO Grade II-IV glioma with radiographic evidence of recurrent or progressive tumor
  • Patient must have received prior radiation therapy for initial treatment of glioma
  • Patients with any number of recurrences are allowed as long as the patient has not undergone re-irradiation
• Brain MRI with contrast demonstrates an enhancing tumor ≤ 6 cm in largest diameter within 60 days prior to registration
• History and physical including neurological exam within 30 days prior to registration
• Karnofsky performance status ≥ 60% within 30 days prior to registration
• Age ≥ 22 years old
• Minimum interval since completion of prior radiation treatment is 8 weeks
  • Patients will only receive re-irradiation if pathology from LITT is consistent with recurrent tumor
• Patients must have signed an approved informed consent
• Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion.
• Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration.