NCT04193228Completed
Muscle Structure, Function and Gait in dHMN
Exploring Muscle Structure, Function and Gait Patterns in People With Distal Hereditary Motor Neuropathy: Natural History and the Effect of Rehabilitation Interventions
Source: ClinicalTrials.gov · Last updated 28 Nov 2023
Brief summary (registry, in English)
Distal Hereditary Motor Neuropathy (dHMN) is a rare inherited neuromuscular disorder. It is characterised by distal weakness. The condition usually manifests in the second decade of life and progresses slowly. Though patients usually have a normal lifespan it is a disabling condition and most eventually need aids to walk. In order to improve walking quality in patient with dHMN, research is needed to understand the impairments that lead to altered gait patterns, and to develop interventions to correct walking gait conservatively. In this proposed trial our goal is to explore the relationships between muscle structure, function and gait patterns for people with Distal Hereditary Motor Neuropathy. Over 12 months, muscle changes in dHMN are going to be observed in terms of structure and function using MRI, myometry and 3D motion analysis. In addition, the effect of a 16 weeks exercises program on muscle structure and function in dHMN is going to be measured by the same observational methods. To address walking gait directly in dHMN, gait patterns with and without wearing carbon fibre ankle foot orthoses (AFO)will be measured using 3D motion analysis.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 11 (actual)
- First submitted
- 23 Oct 2019
- Start date
- 2 Nov 2021
- Primary completion date
- 1 Nov 2023
- Lead sponsor
- University College London Hospitals
- NCT number
- NCT04193228
What you commit to
- Study type: Observational
- Participants enrolled: 11
- From 2 Nov 2021 to the primary completion date, 1 Nov 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Lower limbs surgery planned during the study period or performed within the preceding 12 months.
Other illness
- Known neuromuscular disorder other than dHMN.
- Participant has a history, signs or symptoms of a neuromuscular disorder.
Other
- Bilateral arthrodesis.
- The participant has a contraindication for MRI scan.
- Females who are pregnant, planning pregnancy or breastfeeding.
- The participant has a contraindication for MRI.
- Participants who cannot complete calf and thigh myometry and 3D gait analysis.
- Females who are pregnant, planning pregnancy or breastfeeding.
- \-
Who the study is looking for
- Adult patients aged 18 or above.
- Clinical and electrophysiological features of dHMN.
- Participant is able to give informed consent and has signed the informed consent form.
- Patients who are able to complete calf and thigh myometry and 3D gait analysis.
- Patients who have no contraindication to MRI scanning.
- Participant for objective 3, at least one of the major muscle groups of the ankle, dorsiflexors or plantarflexors, will score over 4/5 on the MRC scale.
- Adult aged 18 or above.
- Participants who have no known neuromuscular disease.
- Participant is able to give informed consent and has signed the informed consent form.
- Participants who are able to complete calf and thigh myometry and 3D gait analysis.
- Participants who have no contraindication to MRI scanning
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Queen Square Centre for Neuromuscular Diseases Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.