NCT04216290Active, not recruitingPhase 2
A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE Trial
Phase II Study of Bladder-SparIng ChemoradiatioN With Durvalumab in Clinical Stage III, Node PosItive BladdeR CancEr (INSPIRE)
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
This phase II trial studies the benefit of adding an immunotherapy drug called MEDI4736 (durvalumab) to standard chemotherapy and radiation therapy in treating bladder cancer which has spread to the lymph nodes. Drugs used in standard chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Immunotherapy with durvalumab may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Giving chemotherapy and radiation therapy with the addition of durvalumab may work better in helping tumors respond to treatment compared to chemotherapy and radiation therapy alone. Patients with limited regional lymph node involvement may benefit from attempt at bladder preservation, and use of immunotherapy and systemic chemotherapy.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 11 (actual)
- First submitted
- 31 Dec 2019
- Start date
- 17 Mar 2021
- Primary completion date
- 4 Feb 2026
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Bladder cancer
- NCT number
- NCT04216290
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 11
- From 17 Mar 2021 to the primary completion date, 4 Feb 2026
- 216 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- STEP 1 (RANDOMIZATION) ELIGIBILITY CRITERIA:
- Patient must be \>= 18 years of age.
- Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 at the time of step 1 randomization.
- Patient must have histologically proven pure or mixed urothelial cancer of the bladder.
- NOTE: Small cell carcinoma is excluded, however other variant histologies are permitted provided a component of urothelial carcinoma is present.
- Patient must have documented node-positive and non-metastatic disease (any T, any N, M0). Node positivity must have been defined prior to receiving any systemic chemotherapy or induction chemotherapy.
- Node positivity can fall into either of the following categories and will be defined by imaging and/or biopsy:
- A lymph node \>= 1.0 cm in short axis on imaging (i.e., CT or MRI or positron emission tomography \[PET\]/CT).
- A lymph node that is \< 1 cm on imaging with either a biopsy confirming involvement with cancer or high suspicion of cancer.
- For patients who have received induction chemotherapy (any type of systemic chemotherapy) for node positive bladder cancer prior to enrollment, there must be no signs of disease progression (CR/partial response \[PR\] or stable disease \[SD\]) based on restaging imaging and cystoscopy, which consists of:
- CT chest, abdomen, and pelvis obtained after completion of induction chemotherapy and within 8 weeks prior to step 1 randomization.
- NOTE: MRI can be used instead of CT per treating physician discretion.
- Cystoscopic evaluation and attempt to perform maximal transurethral resection of bladder tumor (TURBT) performed by the participating urologist after completion of induction chemotherapy and within 12 weeks prior to step 1 randomization. If maximal TURBT is not possible for medical reasons, the enrollment must be discussed and approved with the study chair. Documentation of correspondences with the study chair must be kept on file.
- Patients who achieve CR upon cystoscopy per urologist with no visible tumor (i.e., no need for additional TURBT), are allowed to proceed in the study as adequate resection with no residual disease in bladder.
- For patients who have did not receive induction chemotherapy (any type of systemic chemotherapy) for node positive bladder cancer prior to enrollment, the following must be obtained:
- CT chest, abdomen, and pelvis completed within 8 weeks prior to step 1 randomization.
- NOTE: MRI can be used instead of CT per treating physician discretion.
- Cystoscopic evaluation and attempt to perform maximal TURBT performed by the participating urologist within 12 weeks prior to step 1 randomization. If maximal TURBT is not possible for medical reasons, the enrollment must be discussed and approved with the study chair. Documentation of correspondences with the study chair must be kept on file.
- For patients who may need repeat TURBT if their old TURBT has fallen out of window: If urologist determine no visible tumor (i.e., no need for additional resection) upon cystoscopy, they are allowed to proceed in the study as complete resection.
- Patient must not have received any previous radiation therapy to the pelvic area.
- Patient must agree to undergo CT simulation and treatment planning. If this is the first case registered at the site, then a pre-treatment radiation therapy (RT) review will be required and will take up to 3 business days. The patient cannot start radiation treatment prior to successful completion of this pre-treatment review. Therefore, careful planning is necessary to meet the deadline of starting radiation within 20 business days of step 1 randomization.
- Patient must not have presence of concomitant active upper tract tumors or urethra tumors. History of previously adequately treated non-muscle invasive bladder cancer (NMIBC) are eligible. Previously treated urothelial cancer or histological variant at any site outside of the urinary bladder are allowed, provided they have been Ta/T1/carcinoma in situ (CIS) and post treatment follow up imaging and endoscopic evaluation shows no evidence of disease.
- Patients with previous exposure to immune checkpoint inhibitor for non-muscle invasive disease are eligible. If given for NMIBC, the last dose must have been completed \> 12 months prior to step 1 randomization.
- Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used.
- All patients of childbearing potential must have a blood test or urine study within 14 days prior to step 1 randomization to rule out pregnancy.
- A patient of childbearing potential is defined as any patient, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).
- Patients must not expect to conceive or father children by using accepted and effected method(s) of contraception or by abstaining from sexual intercourse from the time of step 1 randomization for the duration of their participation in the study and continue for at least 3 months after the last dose of protocol treatment.
- Leukocytes \>= 3,000/mcL (obtained \< 14 days prior to step 1 randomization).
- Absolute neutrophil count (ANC) \>= 1,500/mcL (obtained \< 14 days prior to step 1 randomization).
- Hemoglobin \>= 9 g/dL (obtained \< 14 days prior to step 1 randomization).
- Platelets \>= 100,000/mcL (obtained \< 14 days prior to step 1 randomization).
- Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) (obtained \< 14 days prior to step 1 randomization).
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional ULN (obtained \< 14 days prior to step 1 randomization).
- Adequate renal function as evidenced by calculated (Cockcroft's formula) creatinine clearance or 24 hours actual creatinine clearance \>= 30mL/min. The creatinine used to calculate the clearance result must have been obtained within 14 days prior to step 1 randomization. Actual body weight, not ideal body weight, must be used in the calculation.
- Patients with human immunodeficiency virus (HIV) on effective anti-retroviral therapy with undetectable viral load within 6 months of step 1 randomization are eligible for this trial.
- For patients with autoimmune conditions, patient must not have history of prior documented autoimmune disease within 2 years prior to step 1 randomization.
- NOTE: Patient with vitiligo, Grave's disease, eczema or psoriasis (not requiring systemic treatment within 2 years prior to step 1 randomization) are not excluded. Patients with history of completely resolved childhood asthma or atopy are not excluded. Patients with asthma not requiring more than 10 mg/d or equivalent of prednisone are not excluded. Patients with well-controlled hypothyroidism on thyroxine replacement will be eligible as well. Patients with known history of hypoadrenalism on maintenance steroids will be eligible. Patients with type I diabetes mellitus will be eligible, provided their disease is well controlled. History of autoimmune related alopecia is also not an exclusion criteria.
- Patient with active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) are not eligible.
- Patient with a history of and/or confirmed pneumonitis are not eligible.
- Patient with a history of primary immunodeficiency are not eligible.
- Patient with history of allogeneic organ transplant are not eligible.
- Patient must not have an active infection, including:
- Tuberculosis (based on clinical evaluation that includes clinical history, physical examination, and radiographic findings, and tuberculosis testing in line with local practice).
- Hepatitis B (known positive hepatitis B virus \[HBV\] surface antigen \[HBsAg\] result). Past or resolved HBV infection (defined as the presence of hepatitis b core antibody \[anti-HBc\] and absence of HBsAg) are eligible.
- Hepatitis C. Patients positive for hepatitis C (HCV) antibody are eligible only if polymerase chain reaction test is negative for HCV ribonucleic acid (RNA).
- Patient must not have clinically significant liver disease that precludes patient from treatment regimens prescribed on the study (including, but not limited to, active viral, alcoholic or other autoimmune hepatitis, cirrhosis or inherited liver disease).
- Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. Site is encouraged to discuss with the study chair if needed prior to enrollment.
- Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class IIB or better.
- Patient must not have received live attenuated vaccine within 30 days prior to the first dose of durvalumab
- NOTE: Patient, if enrolled, must not receive live vaccine whilst receiving durvalumab and up to 30 days after the last dose of durvalumab.
- NOTE: Patient is permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and coronavirus disease 2019 (COVID-19) (Note: intranasal influenza vaccines, such as Flu-Mist (registered trademark) are live attenuated vaccines and are not allowed). If possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily in order to minimize an overlap of adverse events).
- Patient must not have current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab. The following are exceptions to this criterion:
- Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection).
- Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent.
- Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication).
- Patient must not have any unresolved toxicity (National Cancer Institute \[NCI\] CTCAE grade \>= 2) from previous anti-cancer therapy with the exception of alopecia, vitiligo, and the laboratory values.
- NOTE: Patients with grade \>= 2 neuropathy will be evaluated on a case-by-case basis after consultation with the study chair.
- NOTE: Patients with irreversible toxicity not reasonably expected to be exacerbated by treatment with durvalumab may be included only after consultation with the study chair. Documentation of correspondences with the study chair must be kept on file.
- STEP 2 (REGISTRACTION: ADJUVANT DURVALUMAB VERSUS \[VS\] OBSERVATION) ELIGIBILITY CRITERIA:
- Patient must have evaluation to determine clinical outcome post step 1 treatment (chemoRT+/- durvalumab) with imaging (CT chest, abdomen, and pelvis) (preferably contrast with urogram, if not contraindicated) and cystoscopy with biopsy confirmation to ensure no progression and absence of \>= T2 disease in the bladder. Patient should be registered to step 2 within 28 days from the determination of primary response to step 1 treatment. However, for patients previously on Arm C, an additional 4 week delay to step 2 registration is allowed.
- Patient on the chemoRT+ durvalumab (Arm C) must meet the following:
- Patient must have achieved either complete clinical response OR have demonstrated clinical benefit prior to continuing onto adjuvant durvalumab.
- Patients who are to go on the adjuvant durvalumab (Arm E) must have recovered to at least grade 2 or less immune related adverse event (AE) prior to starting treatment except for immune related alopecia, clinically asymptomatic endocrinopathies. For patients who may have gotten immune related AEs during chemoRT+ durvalumab (Arm C), step 2 registration could be delayed up to additional 4 weeks to ensure recovery to at least grade 2 or lower prior to starting adjuvant therapy. However patients with durvalumab related AEs that require permanent discontinuation of durvalumab will not continue on the adjuvant treatment regardless of the response.
- Patient must not have experienced immune related neurological disorder described as Guillain-Barré syndrome, myasthenic syndrome or myasthenia gravis, or meningoencephalitis during chemoRT+ durvalumab treatment.
- Patient must not have experienced immune related myocarditis or immune related pericarditis during chemoRT+ durvalumab treatment.
- ANC \>= 1,000 mcL (must be obtained \< 28 days prior to step 2 registration).
- Hemoglobin \>= 8g/dL (must be obtained \< 28 days prior to step 2 registration).
- Platelets \>= 70,000 mcL (must be obtained \< 28 days prior to step 2 registration).
- NOTE: If recovery is not achieved, blood counts could be repeated weekly and step 2 registration could be delayed up to additional 4 weeks.
- Patient on the chemoRT arm (Arm D) must have achieved either complete clinical response OR have demonstrated clinical benefit prior to be placed on the observation alone arm (Arm F).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (216)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Providence Regional Cancer System-Aberdeen Coordinator of this site? Confirm its status | Aberdeen | United States | Unknown status |
| University of New Mexico Cancer Center Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| Lehigh Valley Hospital-Cedar Crest Coordinator of this site? Confirm its status | Allentown | United States | Unknown status |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| Mary Greeley Medical Center Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| Providence Alaska Medical Center Coordinator of this site? Confirm its status | Anchorage | United States | Unknown status |
| Anchorage Oncology Centre Coordinator of this site? Confirm its status | Anchorage | United States | Unknown status |
| Alaska Oncology and Hematology LLC Coordinator of this site? Confirm its status | Anchorage | United States | Unknown status |
| Katmai Oncology Group Coordinator of this site? Confirm its status | Anchorage | United States | Unknown status |
| Alaska Breast Care and Surgery LLC Coordinator of this site? Confirm its status | Anchorage | United States | Unknown status |
| Anchorage Associates in Radiation Medicine Coordinator of this site? Confirm its status | Anchorage | United States | Unknown status |
| Alaska Women's Cancer Care Coordinator of this site? Confirm its status | Anchorage | United States | Unknown status |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Duluth Clinic Ashland Coordinator of this site? Confirm its status | Ashland | United States | Unknown status |
| Northwest Wisconsin Cancer Center Coordinator of this site? Confirm its status | Ashland | United States | Unknown status |
| Emory University Hospital/Winship Cancer Institute Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Emory University Hospital Midtown Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Rush-Copley Medical Center Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Mercy Oncology and Hematology - Clayton-Clarkson Coordinator of this site? Confirm its status | Ballwin | United States | Unknown status |
| Johns Hopkins University/Sidney Kimmel Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Eastern Maine Medical Center Coordinator of this site? Confirm its status | Bangor | United States | Unknown status |
| PeaceHealth Saint Joseph Medical Center Coordinator of this site? Confirm its status | Bellingham | United States | Unknown status |
| Saint Charles Health System Coordinator of this site? Confirm its status | Bend | United States | Unknown status |
| Lehigh Valley Hospital - Muhlenberg Coordinator of this site? Confirm its status | Bethlehem | United States | Unknown status |
| Billings Clinic Cancer Center Coordinator of this site? Confirm its status | Billings | United States | Unknown status |
| Illinois CancerCare-Bloomington Coordinator of this site? Confirm its status | Bloomington | United States | Unknown status |
| Saint Luke's Cancer Institute - Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| Massachusetts General Hospital Cancer Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Bozeman Health Deaconess Hospital Coordinator of this site? Confirm its status | Bozeman | United States | Unknown status |
| Essentia Health Saint Joseph's Medical Center Coordinator of this site? Confirm its status | Brainerd | United States | Unknown status |
| Lafayette Family Cancer Center-EMMC Coordinator of this site? Confirm its status | Brewer | United States | Unknown status |
| Trinity Health Medical Center - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Unknown status |
| Saint Joseph Regional Cancer Center Coordinator of this site? Confirm its status | Bryan | United States | Unknown status |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center Coordinator of this site? Confirm its status | Burbank | United States | Unknown status |
| Highline Medical Center-Main Campus Coordinator of this site? Confirm its status | Burien | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Caldwell Coordinator of this site? Confirm its status | Caldwell | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Illinois CancerCare-Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Trinity Health Medical Center - Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Mercy Cancer Center - Cape Girardeau Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Memorial Hospital of Carbondale Coordinator of this site? Confirm its status | Carbondale | United States | Unknown status |
| SIH Cancer Institute Coordinator of this site? Confirm its status | Carterville | United States | Unknown status |
| Illinois CancerCare-Carthage Coordinator of this site? Confirm its status | Carthage | United States | Unknown status |
| Providence Regional Cancer System-Centralia Coordinator of this site? Confirm its status | Centralia | United States | Unknown status |
| Centralia Oncology Clinic Coordinator of this site? Confirm its status | Centralia | United States | Unknown status |
| Christiana Care Health System-Concord Health Center Coordinator of this site? Confirm its status | Chadds Ford | United States | Unknown status |
| Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Unknown status |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Good Samaritan Hospital - Cincinnati Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Bethesda North Hospital Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Siteman Cancer Center at Saint Peters Hospital Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| Providence Cancer Institute Clackamas Clinic Coordinator of this site? Confirm its status | Clackamas | United States | Unknown status |
| Clackamas Radiation Oncology Center Coordinator of this site? Confirm its status | Clackamas | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| Mercy Cancer Center-West Lakes Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| Kootenai Health - Coeur d'Alene Coordinator of this site? Confirm its status | Coeur d'Alene | United States | Unknown status |
| Rocky Mountain Cancer Centers-Penrose Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Penrose-Saint Francis Healthcare Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Mercy Hospital Coordinator of this site? Confirm its status | Coon Rapids | United States | Unknown status |
| Bay Area Hospital Coordinator of this site? Confirm its status | Coos Bay | United States | Unknown status |
| Greater Regional Medical Center Coordinator of this site? Confirm its status | Creston | United States | Unknown status |
| Siteman Cancer Center at West County Hospital Coordinator of this site? Confirm its status | Creve Coeur | United States | Unknown status |
| Carle at The Riverfront Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Essentia Health - Deer River Clinic Coordinator of this site? Confirm its status | Deer River | United States | Unknown status |
| Northwestern Medicine Cancer Center Kishwaukee Coordinator of this site? Confirm its status | DeKalb | United States | Unknown status |
| AdventHealth Porter Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Mercy Medical Center - Des Moines Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Iowa Methodist Medical Center Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Broadlawns Medical Center Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Iowa Lutheran Hospital Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Henry Ford Health Saint John Hospital Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| Essentia Health Cancer Center Coordinator of this site? Confirm its status | Duluth | United States | Unknown status |
| Miller-Dwan Hospital Coordinator of this site? Confirm its status | Duluth | United States | Unknown status |
| Essentia Health Saint Mary's Medical Center Coordinator of this site? Confirm its status | Duluth | United States | Unknown status |
| Pocono Medical Center Coordinator of this site? Confirm its status | East Stroudsburg | United States | Unknown status |
| Marshfield Medical Center-EC Cancer Center Coordinator of this site? Confirm its status | Eau Claire | United States | Unknown status |
| Swedish Cancer Institute-Edmonds Coordinator of this site? Confirm its status | Edmonds | United States | Unknown status |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Carle Physician Group-Effingham Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Illinois CancerCare-Eureka Coordinator of this site? Confirm its status | Eureka | United States | Unknown status |
| Providence Regional Cancer Partnership Coordinator of this site? Confirm its status | Everett | United States | Unknown status |
| Parkland Health Center - Farmington Coordinator of this site? Confirm its status | Farmington | United States | Unknown status |
| Genesys Hurley Cancer Institute Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Hurley Medical Center Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Holy Cross Hospital Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| Mercy Hospital Fort Smith Coordinator of this site? Confirm its status | Fort Smith | United States | Unknown status |
| Unity Hospital Coordinator of this site? Confirm its status | Fridley | United States | Unknown status |
| Saint Luke's Cancer Institute - Fruitland Coordinator of this site? Confirm its status | Fruitland | United States | Unknown status |
| Gibbs Cancer Center-Gaffney Coordinator of this site? Confirm its status | Gaffney | United States | Unknown status |
| Western Illinois Cancer Treatment Center Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Illinois CancerCare-Galesburg Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Northwestern Medicine Cancer Center Delnor Coordinator of this site? Confirm its status | Geneva | United States | Unknown status |
| Nebraska Cancer Specialists/Oncology Hematology West PC Coordinator of this site? Confirm its status | Grand Island | United States | Unknown status |
| Benefis Sletten Cancer Institute Coordinator of this site? Confirm its status | Great Falls | United States | Unknown status |
| Great Falls Clinic Coordinator of this site? Confirm its status | Great Falls | United States | Unknown status |
| Gibbs Cancer Center-Pelham Coordinator of this site? Confirm its status | Greer | United States | Unknown status |
| Penn State Milton S. Hershey Medical Center Coordinator of this site? Confirm its status | Hershey | United States | Unknown status |
| Essentia Health Hibbing Clinic Coordinator of this site? Confirm its status | Hibbing | United States | Unknown status |
| Edward Hines Jr VA Hospital Coordinator of this site? Confirm its status | Hines | United States | Unknown status |
| CHI Saint Vincent Cancer Center Hot Springs Coordinator of this site? Confirm its status | Hot Springs | United States | Unknown status |
| University of Iowa/Holden Comprehensive Cancer Center Coordinator of this site? Confirm its status | Iowa City | United States | Unknown status |
| Swedish Cancer Institute-Issaquah Coordinator of this site? Confirm its status | Issaquah | United States | Unknown status |
| MU Health Care Goldschmidt Cancer Center Coordinator of this site? Confirm its status | Jefferson City | United States | Unknown status |
| Mercy Hospital Joplin Coordinator of this site? Confirm its status | Joplin | United States | Unknown status |
| Logan Health Medical Center Coordinator of this site? Confirm its status | Kalispell | United States | Unknown status |
| CHI Health Good Samaritan Coordinator of this site? Confirm its status | Kearney | United States | Unknown status |
| Illinois CancerCare-Kewanee Clinic Coordinator of this site? Confirm its status | Kewanee | United States | Unknown status |
| University of Tennessee - Knoxville Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| Providence Regional Cancer System-Lacey Coordinator of this site? Confirm its status | Lacey | United States | Unknown status |
| Northwestern Medicine Lake Forest Hospital Coordinator of this site? Confirm its status | Lake Forest | United States | Unknown status |
| Saint Anthony Hospital Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| University of Michigan Health - Sparrow Lansing Coordinator of this site? Confirm its status | Lansing | United States | Unknown status |
| Saint Joseph Hospital East Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| Saint Joseph Radiation Oncology Resource Center Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| AdventHealth Littleton Coordinator of this site? Confirm its status | Littleton | United States | Unknown status |
| Trinity Health Saint Mary Mercy Livonia Hospital Coordinator of this site? Confirm its status | Livonia | United States | Unknown status |
| Longmont United Hospital Coordinator of this site? Confirm its status | Longmont | United States | Unknown status |
| PeaceHealth Saint John Medical Center Coordinator of this site? Confirm its status | Longview | United States | Unknown status |
| Baptist Health Louisville Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Jewish Hospital Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| UofL Health Medical Center Northeast Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Illinois CancerCare-Macomb Coordinator of this site? Confirm its status | Macomb | United States | Unknown status |
| Marshfield Medical Center-Marshfield Coordinator of this site? Confirm its status | Marshfield | United States | Unknown status |
| Sovah Health Martinsville Coordinator of this site? Confirm its status | Martinsville | United States | Unknown status |
| Carle Physician Group-Mattoon/Charleston Coordinator of this site? Confirm its status | Mattoon | United States | Unknown status |
| Loyola University Medical Center Coordinator of this site? Confirm its status | Maywood | United States | Unknown status |
| Idaho Urologic Institute-Meridian Coordinator of this site? Confirm its status | Meridian | United States | Unknown status |
| Saint Luke's Cancer Institute - Meridian Coordinator of this site? Confirm its status | Meridian | United States | Unknown status |
| LSU Healthcare Network / Metairie Multi-Specialty Clinic Coordinator of this site? Confirm its status | Metairie | United States | Unknown status |
| East Jefferson General Hospital Coordinator of this site? Confirm its status | Metairie | United States | Unknown status |
| Mount Sinai Medical Center Coordinator of this site? Confirm its status | Miami Beach | United States | Unknown status |
| Beebe South Coastal Health Campus Coordinator of this site? Confirm its status | Millville | United States | Unknown status |
| Marshfield Medical Center - Minocqua Coordinator of this site? Confirm its status | Minocqua | United States | Unknown status |
| Community Medical Center Coordinator of this site? Confirm its status | Missoula | United States | Unknown status |
| SSM Health Good Samaritan Coordinator of this site? Confirm its status | Mount Vernon | United States | Unknown status |
| Saint Luke's Cancer Institute - Nampa Coordinator of this site? Confirm its status | Nampa | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Nampa Coordinator of this site? Confirm its status | Nampa | United States | Unknown status |
| Helen F Graham Cancer Center Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Medical Oncology Hematology Consultants PA Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Providence Newberg Medical Center Coordinator of this site? Confirm its status | Newberg | United States | Unknown status |
| Louisiana State University Health Science Center Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| University Medical Center New Orleans Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Mercy Hospital Oklahoma City Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Creighton University Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Alegent Health Bergan Mercy Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Alegent Health Lakeside Hospital Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Alegent Health Immanuel Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Illinois CancerCare-Ottawa Clinic Coordinator of this site? Confirm its status | Ottawa | United States | Unknown status |
| VA Palo Alto Health Care System Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| AdventHealth Parker Coordinator of this site? Confirm its status | Parker | United States | Unknown status |
| OSF Saint Francis Radiation Oncology at Pekin Coordinator of this site? Confirm its status | Pekin | United States | Unknown status |
| Illinois CancerCare-Pekin Coordinator of this site? Confirm its status | Pekin | United States | Unknown status |
| OSF Saint Francis Medical Center Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| OSF Saint Francis Radiation Oncology at Peoria Cancer Center Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Illinois CancerCare-Peoria Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Methodist Medical Center of Illinois Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Illinois CancerCare-Peru Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| Valley Radiation Oncology Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| Trinity Health Saint Joseph Mercy Oakland Hospital Coordinator of this site? Confirm its status | Pontiac | United States | Unknown status |
| Michigan Healthcare Professionals Pontiac Coordinator of this site? Confirm its status | Pontiac | United States | Unknown status |
| Providence Portland Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Providence Saint Vincent Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Kootenai Clinic Cancer Services - Post Falls Coordinator of this site? Confirm its status | Post Falls | United States | Unknown status |
| Illinois CancerCare-Princeton Coordinator of this site? Confirm its status | Princeton | United States | Unknown status |
| Saint Mary Corwin Medical Center Coordinator of this site? Confirm its status | Pueblo | United States | Unknown status |
| Beebe Health Campus Coordinator of this site? Confirm its status | Rehoboth Beach | United States | Unknown status |
| Marshfield Medical Center-Rice Lake Coordinator of this site? Confirm its status | Rice Lake | United States | Unknown status |
| Phelps Health Delbert Day Cancer Institute Coordinator of this site? Confirm its status | Rolla | United States | Unknown status |
| Mercy Clinic-Rolla-Cancer and Hematology Coordinator of this site? Confirm its status | Rolla | United States | Unknown status |
| MyMichigan Medical Center Saginaw Coordinator of this site? Confirm its status | Saginaw | United States | Unknown status |
| Sainte Genevieve County Memorial Hospital Coordinator of this site? Confirm its status | Sainte Genevieve | United States | Unknown status |
| Heartland Regional Medical Center Coordinator of this site? Confirm its status | Saint Joseph | United States | Unknown status |
| Essentia Health Sandstone Coordinator of this site? Confirm its status | Sandstone | United States | Unknown status |
| Swedish Medical Center-First Hill Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Swedish Medical Center-Ballard Campus Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| PeaceHealth United General Medical Center Coordinator of this site? Confirm its status | Sedro-Woolley | United States | Unknown status |
| Welch Cancer Center Coordinator of this site? Confirm its status | Sheridan | United States | Unknown status |
| Saint Michael Cancer Center Coordinator of this site? Confirm its status | Silverdale | United States | Unknown status |
| Spartanburg Medical Center Coordinator of this site? Confirm its status | Spartanburg | United States | Unknown status |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Mercy Hospital Springfield Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| CoxHealth South Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Marshfield Medical Center-River Region at Stevens Point Coordinator of this site? Confirm its status | Stevens Point | United States | Unknown status |
| Mercy Hospital South Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Mercy Hospital Saint Louis Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Missouri Baptist Medical Center Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Siteman Cancer Center-South County Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Siteman Cancer Center at Christian Hospital Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Missouri Baptist Sullivan Hospital Coordinator of this site? Confirm its status | Sullivan | United States | Unknown status |
| BJC Outpatient Center at Sunset Hills Coordinator of this site? Confirm its status | Sunset Hills | United States | Unknown status |
| Saint Luke's Cancer Institute - Twin Falls Coordinator of this site? Confirm its status | Twin Falls | United States | Unknown status |
| SMC Center for Hematology Oncology Union Coordinator of this site? Confirm its status | Union | United States | Unknown status |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| The Carle Foundation Hospital Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| PeaceHealth Southwest Medical Center Coordinator of this site? Confirm its status | Vancouver | United States | Unknown status |
| Essentia Health Virginia Clinic Coordinator of this site? Confirm its status | Virginia | United States | Unknown status |
| Providence Saint Mary Regional Cancer Center Coordinator of this site? Confirm its status | Walla Walla | United States | Unknown status |
| Henry Ford Health Warren Hospital Coordinator of this site? Confirm its status | Warren | United States | Unknown status |
| Northwestern Medicine Cancer Center Warrenville Coordinator of this site? Confirm its status | Warrenville | United States | Unknown status |
| Sibley Memorial Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| Methodist West Hospital Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
| Mercy Medical Center-West Lakes Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
| Marshfield Medical Center - Weston Coordinator of this site? Confirm its status | Weston | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Coordinator of this site? Confirm its status | Ypsilanti | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.