NCT04218773TerminatedEarly phase 1
Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study
A Single Center, Pilot Study of Induced Hypertension for Minimizing Infarct Progression in Patients With Acute Large-vessel Occlusion Ischemic Stroke Undergoing Endovascular Therapy
Source: ClinicalTrials.gov · Last updated 14 Oct 2026
Brief summary (registry, in English)
An open label, prospective, single center, pilot trial to assess feasibility and tolerability of short term blood pressure augmentation to minimize infarct progression in acute LVO stroke patients undergoing endovascular therapy.
- Status (registry)
- Terminated
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 15 (actual)
- First submitted
- 20 Dec 2019
- Start date
- 11 Sept 2020
- Primary completion date
- 30 Jun 2022
- Lead sponsor
- Yale University
- Diseases
- Stroke, High blood pressure
- NCT number
- NCT04218773
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in any investigational study in the previous 30 days
- Treatment with Monoamine oxidase inhibitors (MAO-I) within last 7 days
Other illness
- Intracranial hemorrhage (ICH) identified by CT or MRI
- A history of a left ventricular heart failure (NYHA Class ≥ III, or EF < 50%) or angina (either unstable or CCS Grade II) involving symptoms at rest or with ordinary physical activity
- Acute myocardial infarction in the past 6 months
- Signs or symptoms of acute myocardial infarction, including electrocardiogram find-ings, on admission
Lab values
- Elevated serum troponin concentration on admission (>0.1 μg/L)
Other
- Baseline SBP>200 mm Hg
- Inability to access the cerebral vasculature in the opinion of the neurointerventional team
- Contraindication to imaging with MR
- Suspicion of aortic dissection on admission
Who the study is looking for
- Age is ≥18 years
- Patients presenting with anterior circulation acute ischemic stroke
- Enrollment within 24 hours of stroke onset
- Treatment with endovascular thrombectomy
- Arterial occlusion on CTA or MRA of the ICA, M1 or M2
- Mismatch - Using CT or MRI with a Tmax >6 second delay perfusion volume and either CT-rCBF or DWI infarct core volume.
- Mismatch ratio of greater than 1.8, and
- Absolute mismatch volume of greater than 15 ml, and
- Infarct core lesion volume of less than 70 mL
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yale New Haven Hospital Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.