NCT04220814Completed
Evaluation of the Impact of Lesions of the Motor and Proprioceptive Brain and Pan-medullary Pathways on Their Clinically and Electrophysiologically Assessed Function in Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 5 Jan 2026
Brief summary (registry, in English)
Multiple Sclerosis (MS) is the most common acquired neurological disease leading to disability, especially ambulatory, in young adults. To date, the correlation between the number or volume of white matter lesions seen on conventional MRI and the degree of disability of patients remains low to moderate. This phenomenon is known as the "clinical-radiological paradox". In this new project, we hypothesize that an evaluation of the corticospinal pathways including their thoracic medullary portion, as well as taking into account the severity of the lesions using quantitative MRI, will allow the investigators to refine the correlation with ambulatory disability in MS patients. We will complete the evaluation of motor pathways with those of the proprioceptive pathways also strongly involved in ambulation.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 94 (actual)
- First submitted
- 3 Jan 2020
- Start date
- 3 Nov 2020
- Primary completion date
- 3 Oct 2023
- Lead sponsor
- Rennes University Hospital
- Diseases
- Multiple sclerosis
- NCT number
- NCT04220814
What you commit to
- Study type: Interventional
- Participants enrolled: 94
- From 3 Nov 2020 to the primary completion date, 3 Oct 2023
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Corticoids during the last 60 days before inclusion ;
Other illness
- Other neurological disease or Other progressive systemic disease
- History of disease affecting central nervous system
- Familial history of MS
- History of medullar injury
Other
- Patients
- progressive MS ;
- adults subject to legal protection or persons deprived of liberty
- Contraindications to MRI
- Contraindications to motor evoked potentials
- Current pregnancy or breast-feeding
- Healthy volunteers:
- Spinal osteoarthritis which can lead to a spinal hypersignal ;
- adults subject to legal protection or persons deprived of liberty
- Contraindications to MRI
- Contraindications to motor evoked potentials
- Current pregnancy or breast-feeding
Who the study is looking for
- Patients :
- More than 18 years old
- relapsing-remitting multiple sclerosis according to Mac Donald criteria (2010)
- EDSS score at the inclusion from 0 to 4
- With at least 1 symptom of pyramidal injury during clinical exam
- Written informed consent
- Affiliated to a Health Care system
- Healthy Volunteers:
- More than 18 years old
- Written informed consent
- Affiliated to a Health Care system
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| AP-HM Timone Coordinator of this site? Confirm its status | Marseille | France | Unknown status |
| CHU Rennes Coordinator of this site? Confirm its status | Rennes | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.