NCT04225312Active, not recruitingPhase 4
Personalized extended interval dosing of natalizumab in relapsing remitting multiple sclerosis (NEXT-MS)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 29 Jan 2026
Brief summary (registry, in English)
Our objective is to test feasibility and validate safety of personalized extended interval dosing of natalizumab starting from 6 weeks in a large real-life cohort across the Netherlands.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 440 (estimated)
- First submitted
- 22 Jul 2024
- Start date
- 30 Jul 2024
- Lead sponsor
- Amsterdam UMC Stichting
- Diseases
- Multiple sclerosis
- NCT number
- NCT04225312
- EU CT number
- 2024-513105-31-00
- EudraCT number
- 2019-002566-13
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 440
- 17 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- High titer natalizumab (>100AU/ml) antibodies
Other
- Contraindication for yearly magnetic resonance imaging (MRI) (ie, have pacemakers or other contraindicated implanted metal devices, or have claustrophobia that cannot be medically managed)
Who the study is looking for
- Diagnosis of relapsing remitting multiple sclerosis according to the 2017 criteria
- 6 or more consecutive natalizumab infusions
- 18 years or older
- Agreed to participate (written informed consent)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (17)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Flevoziekenhuis Stichting Coordinator of this site? Confirm its status | Almere | Netherlands | Active, not recruiting |
| OLVG Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Active, not recruiting |
| VUMC Stichting Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Active, not recruiting |
| Rijnstate Ziekenhuis Stichting Coordinator of this site? Confirm its status | Arnhem | Netherlands | Active, not recruiting |
| Amphia Hospital Coordinator of this site? Confirm its status | Breda | Netherlands | Active, not recruiting |
| Reinier de Graaf Groep Coordinator of this site? Confirm its status | Delft | Netherlands | Active, not recruiting |
| Slingeland Ziekenhuis Coordinator of this site? Confirm its status | Doetinchem | Netherlands | Active, not recruiting |
| Spaarne Gasthuis Stichting Coordinator of this site? Confirm its status | Haarlem | Netherlands | Active, not recruiting |
| Alrijne Zorggroep Stichting Coordinator of this site? Confirm its status | Leiderdorp | Netherlands | Active, not recruiting |
| St. Antonius Ziekenhuis Coordinator of this site? Confirm its status | Nieuwegein | Netherlands | Active, not recruiting |
| Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Active, not recruiting |
| Maasstad Ziekenhuis Stichting Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Active, not recruiting |
| Ommelander Ziekenhuis Groningen B.V. Coordinator of this site? Confirm its status | Scheemda | Netherlands | Active, not recruiting |
| Jeroen Bosch Ziekenhuis Stichting Coordinator of this site? Confirm its status | 'S-Hertogenbosch | Netherlands | Active, not recruiting |
| Elisabeth-Tweesteden Ziekenhuis Coordinator of this site? Confirm its status | Tilburg | Netherlands | Active, not recruiting |
| Diakonessenhuis Stichting Coordinator of this site? Confirm its status | Utrecht | Netherlands | Active, not recruiting |
| Isala Klinieken Stichting Coordinator of this site? Confirm its status | Zwolle | Netherlands | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.