NCT04229992Completed
Calcium: Magnesium Balance, Microbiota, and Necroptosis and Inflammation
Source: ClinicalTrials.gov · Last updated 28 Jan 2025
Brief summary (registry, in English)
Transient receptor potential melastatin 7 (TRPM7), a magnesium (Mg) -regulated chanzyme possessing both ion channel and kinase activities, has a much stronger affinity to Mg2+ than calcium (Ca)2+. We previously reported that individuals with the TRPM7 GA/AA genotype and consumed diets high in Ca:Mg ratio had an increased risk of colorectal polyps. The TRPM7 gene was also observed to possess "driver" mutations that contribute to developing multiple cancers. However, the molecular mechanism remains unclear. To identify if the gut microbiota plays a role in this association, we will investigate whether optimizing Ca:Mg intake ratios to 2.3 altered the abundance of the microbes (e.g. associated with TRPM7 genotype and the risk of metachronous polyps) at the genus level in at least one sample type among stool, swab and tissue in a double-blind 2x2 factorial (TRPM7 genotype and Ca:Mg ratios) randomized trial (Personalized Prevention of Colorectal Cancer Trial, NCT01105169).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 250 (actual)
- First submitted
- 12 Jan 2020
- Start date
- 5 May 2017
- Primary completion date
- 28 Feb 2024
- Lead sponsor
- Vanderbilt University Medical Center
- Diseases
- Colorectal cancer
- NCT number
- NCT04229992
What you commit to
- Study type: Interventional
- Participants enrolled: 250
- From 5 May 2017 to the primary completion date, 28 Feb 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Participants did not provide any stool/swab/rectal biopsy sample in the parent study
Who the study is looking for
- Participants from the parent study (Personalized Prevention of Colorectal Cancer Trial, NCT#01105169, IRB#100106)
Age in the registry: 40 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.