NCT04250493Recruiting
Insulin Resistance in Multiple System Atrophy
Source: ClinicalTrials.gov · Last updated 20 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder. The pathologic hallmark is the accumulation of aggregated alpha-synuclein in oligodendrocytes forming glial cytoplasmic inclusions. Some symptomatic treatments are available while disease-modification remains an unmet treatment need. Post-mortem findings suggest insulin resistance, i.e. reduced insulin signaling, in the brains of MSA patients. The aim of this study is to complete the target validation of insulin resistance for future treatment trials.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 124 (estimated)
- First submitted
- 29 Jan 2020
- Start date
- 28 Oct 2020
- Primary completion date
- 28 Oct 2026
- Lead sponsor
- University Hospital, Bordeaux
- NCT number
- NCT04250493
What you commit to
- Study type: Interventional
- Planned participants: 124
- From 28 Oct 2020 to the primary completion date, 28 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with corticosteroids, estrogen, atypical antipsychotics, and anti-retroviral agents
Other illness
- Presence of a diabetes
- Any other neurologic disorder
Other
- For patients and controls:
- Patient under tutelage
- Patient unable to give consent
- Pregnancy and breastfeeding
- MOCA ≤21
- Contraindication to perform an MRI
Who the study is looking for
- Patients :
- Patients suffering from "possible" or "probable" MSA according to clinical consensus criteria (Gilman et al., 2008).
- Age \> 30
- Written informed consent
- Patient covered by the national health system
- Controls:
- Patients not suffering from a neurologic disorder
- Age \> 30
- Written informed consent
- Patient covered by the national health system
Age in the registry: 30 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.