NCT04261972Active, not recruiting
Cell-free DNA in Hereditary And High-Risk Malignancies 1
Early Detection of Cancer in High-risk Patients Through Cell-free DNA 1
Source: ClinicalTrials.gov · Last updated 14 Jan 2026
Brief summary (registry, in English)
The goal of this study is to develop an effective, sensitive blood test that can detect early tumours in patients with known or suspected hereditary cancer syndromes (HCS). If this new blood test is accurate, it could be used to screen patients for cancer and allow for earlier cancer detection. The study will also use questionnaires and interviews to understand how patients feel about incorporating these tests into routine medical care, and the perceptions of the medical value of test results.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 1416 (actual)
- First submitted
- 2 Jan 2020
- Start date
- Jul 2018
- Primary completion date
- Dec 2024
- Lead sponsor
- University Health Network, Toronto
- Diseases
- Ovarian cancer
- NCT number
- NCT04261972
What you commit to
- Study type: Observational
- Participants enrolled: 1416
- From Jul 2018 to the primary completion date, Dec 2024
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- 1\. Individuals that do not meet the outlined inclusion criteria.
Who the study is looking for
- Individual with any known or suspected hereditary cancer predisposition (i.e. individuals with an identified pathogenic or likely pathogenic variant in a cancer predisposition gene and/or a family history of cancer without an identified gene mutation) at any stage in their cancer journey (ie: cancer survivor, unaffected with cancer, current cancer patient).
- Individual must be greater than 18 years of age
- Individual must speak English or French to participate in the qualitative interview and/or survey
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IWK Health Centre Coordinator of this site? Confirm its status | Halifax | Canada | Unknown status |
| Jewish General Hospital Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Eastern Health Coordinator of this site? Confirm its status | St. John's | Canada | Unknown status |
| Sinai Health System Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| University Health Network Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Women's College Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| BC Cancer Agency Coordinator of this site? Confirm its status | Vancouver | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.