NCT04273022Completed
Effect of Exercise on Biomarkers in SCT
The Effect of Exercise on Resting Biomarkers in Subjects With Sickle Cell Trait
Source: ClinicalTrials.gov · Last updated 28 Jan 2025
Brief summary (registry, in English)
This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adverse events in athletes and warfighters with SCT upon protracted, repeated, strenuous exertion. Changes in biomarkers post-exercise compared to pre-exercise (and compared to healthy controls) suggest activation of the associated pathway(s) which may contribute to exercise-related events in athletes and warfighters and subclinical complications in non-athletes.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 12 (actual)
- First submitted
- 11 Feb 2020
- Start date
- 27 Dec 2021
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- St. Louis University
- NCT number
- NCT04273022
What you commit to
- Study type: Interventional
- Participants enrolled: 12
- From 27 Dec 2021 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- have other self-reported conditions known to cause blood coagulation activation, myocyte destruction, hemolysis, chronic inflammation, or renal disease
- any condition that places subjects at risk during exercise.
Other
- Subjects will be excluded if they:
- weigh less than 110 pounds,
- are pregnant,
- have hemoglobinopathies (other than sickle cell trait) as determined by Hb electrophoresis,
Who the study is looking for
- Health subjects with sickle cell trait (AS)
- Ages 18-70 years
- Healthy subjects without sickle cell trait (AA)
- Ages 18-70 years
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Saint Louis University Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.